生长激素在辅助生殖助孕中对高龄妇女PGT-A周期结局影响的研究进展
Research Progress on the Impact of Growth Hormone on PGT-A Cycle Outcomes in Advanced-Age Women during Assisted Reproduction
DOI: 10.12677/acm.2026.1693168, PDF,    科研立项经费支持
作者: 楚欣蕊*, 刘毛毛：济宁医学院临床医学院(附属医院)，山东 济宁；马亚兰：济宁医学院附属医院生殖医学中心，山东 济宁
关键词: 生长激素；辅助生殖技术；高龄妇女；PGT-A；妊娠结局；Growth Hormone； Assisted Reproductive Techniques； Advanced-Age Women； PGT-A； Pregnancy Outcome
摘要: 在辅助生殖技术领域，随着女性生育年龄推迟，高龄妇女的胚胎染色体非整倍体率显著升高。尽管胚胎植入前遗传学筛查(PGT-A)可筛选整倍体胚胎，但在高龄患者中每周期可获得整倍体胚胎的比例仍然较低。生长激素(GH)作为一种重要的内分泌调节因子，近年来研究发现其可能通过改善卵母细胞线粒体功能及减数分裂过程中的染色体分离，从而提高高龄患者PGT-A周期中的整倍体胚胎获得率。本文系统综述GH在高龄妇女PGT-A周期中的应用现状，作用机制及其对胚胎质量和妊娠结局的影响，旨在为临床实践提供更为科学的依据，推动个体化辅助生殖治疗的发展。
Abstract: In the field of assisted reproductive technology, with the delay in female childbearing age, the rate of embryonic chromosomal aneuploidy is significantly increased in women of advanced maternal age. Although preimplantation genetic testing for aneuploidy (PGT-A) can screen for euploid embryos, the proportion of cycles yielding at least one euploid embryo remains low in this population. Growth hormone (GH), a key endocrine regulator, has recently been shown to potentially improve oocyte mitochondrial function and chromosome segregation during meiosis, thereby enhancing the euploid embryo acquisition rate in PGT-A cycles among advanced-age women. This article systematically reviews the current application, mechanisms of action, and effects of GH on embryo quality and pregnancy outcomes in PGT-A cycles for advanced-age women, aiming to provide scientific evidence for clinical practice and promote individualized assisted reproductive therapy.
文章引用：楚欣蕊, 马亚兰, 刘毛毛. 生长激素在辅助生殖助孕中对高龄妇女PGT-A周期结局影响的研究进展[J]. 临床医学进展, 2026, 16(9): 1320-1328. https://doi.org/10.12677/acm.2026.1693168

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