C1ORF112在肝细胞癌中的表达、功能及临床意义研究进展

Research Progress on the Expression, Function and Clinical Significance of C1ORF112 in Hepatocellular Carcinoma

摘要: 目的：系统梳理染色体1开放阅读框112 (C1ORF112)在肝细胞癌(HCC)中的表达特征、临床预后价值及分子机制研究进展，评估其作为新型生物标志物和潜在治疗靶点的可行性。方法：检索PubMed、Web of Science、CNKI等数据库中关于C1ORF112与肝细胞癌的相关文献，对现有证据进行归纳、整合与评述。结果：C1ORF112在HCC组织中普遍高表达，其表达水平与肿瘤病理分期呈显著正相关，且高表达患者的总生存期明显缩短。约8%的HCC患者存在C1ORF112基因拷贝数扩增，扩增与较差的无进展生存期和无病生存期显著相关。在分子层面，C1ORF112与RAD51、FIGNL1等DNA修复相关蛋白相互作用，其共表达基因富集于细胞周期和有丝分裂调控通路。结论：C1ORF112有望成为HCC的新型预后生物标志物和潜在治疗靶点。然而，目前尚缺乏针对HCC的大规模前瞻性临床验证及体内功能研究，其具体调控网络和临床转化路径仍需深入探索。

Abstract: Objectives: To systematically review the expression characteristics, clinical prognostic value, and molecular mechanisms of Chromosome 1 Open Reading Frame 112 (C1ORF112) in hepatocellular carcinoma (HCC), and to evaluate its feasibility as a novel biomarker and potential therapeutic target. Methods: Relevant literature on C1ORF112 and HCC was retrieved from PubMed, Web of Science, and CNKI databases, and the available evidence was summarized, integrated, and critically appraised. Results: C1ORF112 is commonly overexpressed in HCC tissues, and its expression level is significantly positively correlated with pathological stage. Patients with high C1ORF112 expression have significantly shorter overall survival. Approximately 8% of HCC patients harbor C1ORF112 gene copy number amplification, which is significantly associated with worse progression-free survival and disease-free survival. At the molecular level, C1ORF112 physically interacts with DNA repair-related proteins including RAD51 and FIGNL1, and its co-expressed genes are enriched in cell cycle and mitotic regulation pathways. Conclusions: C1ORF112 holds promise as a novel prognostic biomarker and potential therapeutic target for HCC. However, large-scale prospective clinical validation and in vivo functional studies specifically for HCC are still lacking, and the precise regulatory networks and translational pathways require further investigation.