直肠黏膜脱垂综合征的中西医治疗进展
Advances in the Treatment of Rectal Mucosal Prolapse Syndrome with Integrated Traditional Chinese and Western Medicine
摘要: 直肠黏膜脱垂综合征(Rectal Mucosal Prolapse Syndrome, RMPS)是肛肠科常见的盆底功能障碍性疾病,以直肠黏膜与肌层分离、脱垂或套叠为主要病理特征,临床表现为肛门坠胀、排便梗阻及不完全性脱垂等,严重影响患者生活质量。近年来,西医在手术方式上不断革新,从药物保守治疗、传统经会阴手术到腹腔镜乃至机器人辅助手术,疗效显著提升;中医则从辨证论治、针灸外治、注射固脱等多维度形成了独特的诊疗体系。中西医结合治疗模式在降低复发率、改善术后功能方面展现出独特优势。因此,文章通过系统检索近年来国内外相关文献,从发病机制、治疗方法等方面系统综述直肠黏膜脱垂综合征的中西医治疗进展,以期为临床诊疗提供参考。
Abstract: Rectal mucosal prolapse syndrome (RMPS) is a common pelvic floor dysfunctional disease in proctology, primarily characterized by separation of the rectal mucosa from the muscular layer, prolapse, or intussusception. Clinical manifestations include anal tenesmus, obstructive defecation, and incomplete prolapse, severely affecting patients’ quality of life. In recent years, Western medicine has continuously innovated surgical approaches, evolving from conservative pharmacological treatment and traditional perineal surgery to laparoscopic and even robot-assisted procedures, with significantly improved therapeutic outcomes. Traditional Chinese medicine (TCM), on the other hand, has developed a distinctive diagnostic and therapeutic system through multiple dimensions such as syndrome differentiation-based treatment, acupuncture and external therapies, and injection fixation. The integrated Chinese and Western medicine treatment model has demonstrated unique advantages in reducing recurrence rates and improving postoperative function. Therefore, by systematically reviewing recent domestic and international literature, this article summarizes the progress in the treatment of rectal mucosal prolapse syndrome from aspects including pathogenesis and therapeutic methods, aiming to provide a reference for clinical diagnosis and treatment.
文章引用:赵淑缘, 闫晓丹, 马梦迪, 孟儒, 陈敏. 直肠黏膜脱垂综合征的中西医治疗进展[J]. 中医学, 2026, 15(9): 233-242. https://doi.org/10.12677/tcm.2026.159506

参考文献

[1] Cariou de Vergie, L., Venara, A., Duchalais, E., Frampas, E. and Lehur, P.A. (2017) Internal Rectal Prolapse: Definition, Assessment and Management in 2016. Journal of Visceral Surgery, 154, 21-28.
https://doi.org/10.1016/j.jviscsurg.2016.10.004
[2] 任东林, 张恒. 孤立性直肠溃疡综合征与直肠脱垂综合征的诊断与治疗[J]. 中国实用外科杂志, 2020, 40(5): 520-524.
[3] McNevin, M.S. (2024) Evaluation and Management of Rectal Prolapse. Surgical Clinics of North America, 104, 557-564.
https://doi.org/10.1016/j.suc.2023.12.002
[4] 李华山, 崔国策. 李华山教授注射治疗直肠脱垂经验[J]. 中国中西医结合杂志, 2017, 37(12): 1429-1430.
[5] Blaker, K. and Anandam, J. (2017) Functional Disorders: Rectoanal Intussusception. Clinics in Colon and Rectal Surgery, 30, 5-11.
https://doi.org/10.1055/s-0036-1593433
[6] 中国医师协会肛肠医师分会. 直肠脱垂外科诊治中国专家共识(2022版) [J]. 中华胃肠外科杂志, 2022, 25(12): 1081-1088.
[7] 温翠婷, 袁丽宜, 习元堂, 等. 补中益气汤加减治疗直肠脱垂Meta分析[J]. 中国中医药信息杂志, 2019, 26(12): 90-96.
[8] 伏林, 冯春玲, 庄元旦, 等. 多次复发直肠脱垂中西医治疗1例及文献回顾[J]. 上海中医药大学学报, 2025, 39(S1): 20-23.
[9] 李志鹏, 柯敏辉. 建立直肠脱垂模型的动物选择与常用造模方法分析[J]. 中国中医基础医学杂志, 2022, 28(4): 533-535.
[10] 刘明欣, 邓洋洋, 谷峰. 痔类疾病诊疗理论研究[J]. 辽宁中医杂志, 2016, 43(6): 1180-1183.
[11] 李倩蕾, 刘芳, 韩宝. 韩宝治疗脱肛病的临床经验[J]. 中华中医药杂志, 2019, 34(8): 3538-3540.
[12] Zeineddine, J., Bordeianou, L. and Krautkramer, K.A. (2026) Rectal Prolapse. Surgical Clinics of North America, 106, 77-91.
https://doi.org/10.1016/j.suc.2025.08.007
[13] 梅志彪, 魏东. 从手术方式的改变看直肠脱垂外科治疗的进展[J]. 中华胃肠外科杂志, 2025, 28(12): 1396-1403.
[14] Loh, K.C. and Umanskiy, K. (2021) Ventral Rectopexy. Clinics in Colon and Rectal Surgery, 34, 62-68.
https://doi.org/10.1055/s-0040-1714288
[15] Wallace, S.L., Gee, A.D. and Das, D. (2025) Multicompartment Pelvic Floor Prolapse: Advances in Diagnosis and Surgical Management. Current Opinion in Obstetrics & Gynecology, 37, 416-420.
https://doi.org/10.1097/gco.0000000000001069
[16] van der Schans, E.M., Paulides, T.J.C., Wijffels, N.A. and Consten, E.C.J. (2018) Management of Patients with Rectal Prolapse: The 2017 Dutch Guidelines. Techniques in Coloproctology, 22, 589-596.
https://doi.org/10.1007/s10151-018-1830-1
[17] 刘佃温, 杨会举, 刘翔. 功能性排便障碍的整合诊治经验[J]. 中国中西医结合杂志, 2017, 37(12): 1425-1426.
[18] 陈勇, 黄璇, 高献明, 等. 中药熏洗联合生物反馈对直肠内脱垂吻合器痔上黏膜环切术术后临床疗效[J]. 中华中医药杂志, 2021, 36(2): 1192-1196.
[19] 樊文彬, 孙锋, 杨向东. 直肠脱垂手术路径及手术方式的选择[J]. 中华消化外科杂志, 2019, 18(8): 806-810.
[20] Emile, S.H., Elfeki, H., Shalaby, M., Sakr, A., Sileri, P. and Wexner, S.D. (2017) Perineal Resectional Procedures for the Treatment of Complete Rectal Prolapse: A Systematic Review of the Literature. International Journal of Surgery, 46, 146-154.
https://doi.org/10.1016/j.ijsu.2017.09.005
[21] 许裕杰, 张迪, 张恒, 等. Altemeier术和Delorme术治疗直肠脱垂的疗效分析[J]. 中华胃肠外科杂志, 2019, 22(12): 1170-1176.
[22] 刘容, 肖天保, 陈江, 等. 腹腔镜下直肠脱垂悬吊固定并乙状结肠折叠术治疗完全性直肠脱垂患者的临床效果[J]. 重庆医科大学学报, 2024, 49(3): 346-350.
[23] 屈景辉, 贺佳蓓, 杨向东. 肛门括约肌成形术在直肠脱垂经会阴直肠乙状结肠切除术中的应用价值[J]. 中国微创外科杂志, 2026, 26(3): 169-173.
[24] 戴俏琼, 邵钦树, 蒋梦玲, 等. Altemeier手术联合自体肛门括约肌紧缩术治疗Ⅱ、Ⅲ度直肠脱垂合并肛门松弛40例的疗效分析[J]. 中华胃肠外科杂志, 2021, 24(12): 1116-1118.
[25] 张廷涛, 张秋雷, 江从庆, 等. 经会阴直肠乙状结肠部分切除手术并发症防治(附48例报告) [J]. 中国实用外科杂志, 2016, 36(10): 1094-1095+1100.
[26] 张正国, 杨光, 杨勇, 等. 量体裁衣式经肛门吻合器直肠部分切除术治疗直肠脱垂的临床研究[J]. 中华胃肠外科杂志, 2018, 21(3): 342-344.
[27] 阮宁, 徐卓荦. dPPH手术与TST STARR+术治疗直肠黏膜脱垂的临床对比研究[J]. 福建医科大学学报, 2016, 50(4): 256-259.
[28] 徐乐臣, 沈家华, 杨新庆. 经肛吻合器直肠切除术治疗女性出口梗阻型便秘临床效果观察[J]. 中国医学物理学杂志, 2021, 38(4): 480-484.
[29] Hori, T., Yasukawa, D., Machimoto, T., et al. (2018) Surgical Options for Full-Thickness Rectal Prolapse: Current Status and Institutional Choice. Annals of Gastroenterology, 31, 188-197.
https://doi.org/10.20524/aog.2017.0220
[30] Kersting, S., Jung, K.P. and Berg, E. (2017) Alloplastic Material in Prolapse Surgery: Indications and Postoperative Outcome of Ventral Rectopexy. Der Chirurg, 88, 141-146.
https://doi.org/10.1007/s00104-016-0264-4
[31] Perry, W.R.G., Christensen, P., Collinson, R.J., Cornish, J.A., D’Hoore, A., Gurland, B.H., et al. (2025) Ventral Rectopexy: An International Expert Panel Consensus and Review of Contemporary Literature. Diseases of the Colon & Rectum, 68, 593-607.
https://doi.org/10.1097/dcr.0000000000003656
[32] 牛丽云, 田利军, 杨建永, 等. 腹腔镜直肠腹侧固定术治疗直肠脱垂的疗效分析[J]. 中华普通外科杂志, 2019, 34(1): 35-38.
[33] 李昂, 周毕军, 王志伟. 不同手术方式治疗重度老年性直肠脱垂的效果[J]. 中国老年学杂志, 2021, 41(11): 2304-2307.
[34] 陈鸣旺, 高舒影, 罗宏标, 等. 腹腔镜腹侧网状直肠固定术治疗女性直肠脱垂的术后功能评价[J]. 中国现代医学杂志, 2021, 31(5): 96-100.
[35] Bao, X., Wang, H., Song, W., Chen, Y. and Luo, Y. (2021) Meta-Analysis on Current Status, Efficacy, and Safety of Laparoscopic and Robotic Ventral Mesh Rectopexy for Rectal Prolapse Treatment: Can Robotic Surgery Become the Gold Standard? International Journal of Colorectal Disease, 36, 1685-1694.
https://doi.org/10.1007/s00384-021-03885-y
[36] 李震, 王世豪, 李国宾, 等. 机器人和腹腔镜及开腹手术治疗重度直肠脱垂的临床效果比较[J]. 中华胃肠外科杂志, 2020, 23(12): 1187-1193.
[37] 高林丰, 董森, 李川, 等. 达芬奇机器人手术系统改良Orr-Loygue直肠补片固定术治疗直肠脱垂[J]. 中华胃肠外科杂志, 2022, 25(7): 631.
[38] Yasar, N.F., Waked, W., Sturiale, A., Fabiani, B. and Naldini, G. (2024) Could Robotic‐Assisted Surgery Reduce Mesh‐related Complications after Ventral Mesh Rectopexy? Experience of a Tertiary Centre and Systematic Review of the Literature. Colorectal Disease, 26, 609-621.
https://doi.org/10.1111/codi.16938
[39] Hess, G.F., Nocera, F., Taha-Mehlitz, S., Christen, S., von Strauss Und Torney, M. and Steinemann, D.C. (2024) Mesh-Associated Complications in Minimally Invasive Ventral Mesh Rectopexy: A Systematic Review. Surgical Endoscopy, 38, 7073-7082.
https://doi.org/10.1007/s00464-024-11369-7
[40] Flynn, J., Larach, J.T., Kong, J.C.H., Warrier, S.K. and Heriot, A. (2021) Robotic versus Laparoscopic Ventral Mesh Rectopexy: A Systematic Review and Meta-Analysis. International Journal of Colorectal Disease, 36, 1621-1631.
https://doi.org/10.1007/s00384-021-03904-y
[41] 魏东, 张剑锋, 曹永丽, 等. 盆底韧带引导的腹腔镜盆底修复治疗直肠内脱垂的疗效分析[J]. 中华普通外科杂志, 2019, 34(1): 31-34.
[42] 吕兵兵, 曹永丽, 李明, 等. 盆底整体理论指导下完全性直肠脱垂的手术疗效分析[J]. 中华普通外科杂志, 2022, 37(6): 439-442.
[43] 梅志彪, 曹永丽, 吕兵兵, 等. 基于膜解剖的盆底自体筋膜整体修补术治疗完全性直肠脱垂的疗效观察[J]. 中华胃肠外科杂志, 2025, 28(12): 1441-1447.
[44] 陈正鑫, 江滨, 倪敏, 等. 腹腔镜与开腹直肠悬吊固定术治疗直肠全层脱垂的临床疗效比较[J]. 实用医学杂志, 2019, 35(17): 2709-2712.
[45] 于杰, 龚治林, 周启昌, 等. 成人直肠脱垂个体化诊治外科手术治疗探讨[J]. 重庆医学, 2017, 46(17): 2412-2415.
[46] 万星阳, 金鑫, 许裕杰, 等. 黄芪治疗肺脾气虚型直肠内脱垂的疗效及机制研究[J]. 中国中医基础医学杂志, 2020, 26(9): 1293-1296.
[47] 段冰倩, 高记华, 戚文月, 等. 基于道术结合理论研究中医药改善直肠脱垂术后排便功能的疗效价值分析[J]. 辽宁中医杂志, 2025, 52(1): 118-121.
[48] 李泰庚, 杨康, 张茂祥, 等. 针灸治疗脱肛的同功穴[J]. 中国老年学杂志, 2017, 37(17): 4318-4319.
[49] 张妍, 李春晖, 刘蒙, 等. 隔药灸气海穴结合穴位埋线治疗脱肛26例[J]. 中国针灸, 2021, 41(3): 268.
[50] 李冠路, 高记华, 徐丹阳, 等. 中医硬化注射疗法治疗肛肠疾病现状与进展[J]. 中华中医药杂志, 2022, 37(6): 3351-3355.
[51] 崔国策, 祝子贝, 李华山. 消痔灵直肠周围间隙八点注射法治疗完全性直肠脱垂的疗效观察[J]. 中华中医药杂志, 2017, 32(5): 2315-2318.
[52] 陈琴, 王晓锋, 贝绍生, 等. 基于倾向性评分匹配的消痔灵单层八步与双层四步注射治疗直肠脱垂的疗效比较[J]. 中华中医药杂志, 2022, 37(10): 6148-6152.
[53] 周世勇, 艾飞, 刘德武, 等. TST术联合聚桂醇点状注射治疗混合痔合并直肠黏膜内脱垂临床观察[J]. 中国全科医学, 2021, 24(S2): 76-79.