根治性放疗对局部晚期宫颈鳞癌患者治疗效果的分析

Analysis of the Therapeutic Effect of Radical Radiotherapy on Patients with Locally Advanced Cervical Squamous Cell Carcinoma

摘要: 目的：本文研究分析根治性放疗对局部晚期宫颈鳞癌患者的治疗效果。方法：回顾性分析收治的80例宫颈鳞癌患者的病例资料，按照随机数字表法将其分为2组，每组40人。对照组采用单纯调强放疗，研究组采用根治性放疗。比较两组总有效率、疾病控制率、近期治疗效果、血清肿瘤标志物水平、不良反应等因素。结果：研究组总有效率82.50%高于对照组60.00%，研究组疾病控制率92.50%高于对照组75.00%，差异有统计学意义(P < 0.05)；治疗后，研究组血清肿瘤标志物AFP、CA125、CEA、SCC的水平均低于对照组，差异有统计学意义(P < 0.05)；研究组治疗期间白细胞计数减少、中性粒细胞计数减少和胃肠道反应的发生率显著高于对照组，差异有统计学意义(P < 0.05)。结论：根治性放疗对局部晚期宫颈鳞癌患者治疗效果显著，能显著降低患者血清肿瘤标志物水平，但治疗期间不良反应更重，需要及早干预。

Abstract: Objective: To study and analyze the therapeutic effect of radical radiotherapy on patients with locally advanced cervical squamous cell carcinoma. Methods: The case data of 80 patients with cervical squamous cell carcinoma were retrospectively analyzed. They were divided into two groups according to the random number table method, with 40 people in each group. The control group was treated with intensity-modulated radiotherapy alone, and the study group was treated with radical radiotherapy. The total effective rate, disease control rate, tumor marker levels, adverse reactions, recent treatment effects and other factors were compared between the two groups. Results: The total effective rate of the study group was 82.50% higher than that of the control group, which was 60.00%. The disease control rate of the study group was 92.50% higher than that of the control group, which was 75.00%. The difference was statistically significant (P < 0.05). After treatment, the levels of the serum tumor markers including AFP, CA125, CEA, and SCC in the study group were all lower than those in the control group, and the difference was statistically significant (P < 0.05); the reduction in white blood cell count, neutrophil count, and incidence of gastrointestinal reactions in the study group during treatment were significant (P < 0.05). Conclusion: Radical radiotherapy has a significant therapeutic effect on patients with locally advanced cervical squamous cell carcinoma and can reduce the levels of serum tumor markers in patients. However, the adverse reactions during treatment are more severe and require intervention.