钌催化芳烃间位C-H官能团化研究进展
Research Progress in Ruthenium‑Catalyzed Meta‑C‑H Functionalization of Arenes
DOI: 10.12677/jocr.2026.143036, PDF,   
作者: 朱 玲：浙江师范大学化学与材料科学学院，浙江 金华
关键词: 钌催化；α-活化；间位C‑H官能化；导向基团；Ruthenium Catalysis； α-Activation； Meta‑C‑H Functionalization； Directing Group
摘要: 芳烃间位C‑H键选择性官能化是有机合成领域极具挑战性的研究方向。传统钌催化C‑H活化反应主要得到邻位官能化产物，Ru (II)催化发展出独特的α‑活化策略，依靠导向基团螯合辅助完成邻位环钌金属化，再经亲电取代或自由基过程，在Ru‑C键对位(芳烃底物间位)实现位点选择性转化。本文在Phipps课题组综述基础上，围绕α‑活化机理系统总结钌催化芳烃间位磺酰化、烷基化、卤化、硝化反应，梳理可脱除导向基团与多步串联转化策略，剖析该领域现存短板，为开发新型间位选择性C‑H活化方法提供参考。
Abstract: Meta‑selective functionalization of aromatic C‑H bonds represents a highly challenging research direction in organic synthesis. Conventional ruthenium‑catalyzed C‑H activation reactions predominantly afford ortho‑functionalized products. Ru(II) catalysis enables a distinctive α‑activation strategy, in which chelation‑assisted directing‑group coordination triggers ortho‑cycloruthenation. Subsequent electrophilic substitution or radical processes occur at the para‑position of the Ru‑C bond, namely the meta‑position of aromatic substrates, to achieve site‑selective transformation. On the basis of the review reported by Phipps research group, this paper systematically summarizes ruthenium‑catalyzed meta‑sulfonylation, alkylation, halogenation and nitration reactions of arenes based on the α‑activation mechanism. Removable directing‑group protocols and multi‑step tandem transformation strategies are sorted out, and the existing bottlenecks in this field are analyzed, so as to provide references for developing novel meta‑selective C‑H activation methodologies.
文章引用：朱玲. 钌催化芳烃间位C-H官能团化研究进展[J]. 有机化学研究, 2026, 14(3): 416-427. https://doi.org/10.12677/jocr.2026.143036

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