基于CiteSpace可视化分析我国乳腺癌化疗相关认知障碍研究热点及趋势

Research Hotspots and Trends of Chemotherapy-Related Cognitive Impairment in Breast Cancer in China: A CiteSpace-Based Visualization Analysis

摘要: 目的：乳腺癌化疗相关认知障碍(Chemotherapy-Related Cognitive Impairment, CRCI)严重影响患者的生存质量，已成为肿瘤护理领域备受关注的研究课题，但该领域的研究现状、热点与趋势尚缺乏系统的可视化梳理。本文利用CiteSpace软件对乳腺癌化疗相关认知障碍相关研究进行可视化分析，了解其研究现状、热点和趋势，为未来护理提供新思路。方法：检索2000年1月1日至2025年10月31日中国知网(CNKI)与Web of Science (WOS)数据库中乳腺癌CRCI相关文献进行可视化分析，回顾了年度发文量的变化趋势，归纳了作者与机构的合作网络特征，分析了关键词共现与聚类所反映的研究主题分布。结果：知网纳入文献141篇，WOS纳入文献517篇。本领域年度发文呈周期性波动的趋势，国际上形成了稳定的合作团队，部分机构之间合作较为紧密。化疗为乳腺癌CRCI重要的影响因素；认知障碍、记忆力减退为乳腺癌CRCI常见的表现形式。结论：化疗是该领域最为核心的影响因素，认知障碍、记忆力减退及生活质量是常见的临床表现与结局指标；国际上已形成若干稳定的科研合作团队，尤其在北美与欧洲地区机构间合作较为紧密，但国内机构与作者合作网络稀疏，尚未形成稳定的核心作者群，跨地区协作网络仍显薄弱。基于上述发现，本文提出未来研究应进一步加强不同国家、机构与学者之间的深度协作；分析表明，非药物干预、认知训练、心理社会支持及个性化护理模式可能成为该领域的研究前沿与热点，为乳腺癌CRCI的临床护理实践与后续研究提供了明确的发展方向。

Abstract: Objective: Chemotherapy-Related Cognitive Impairment (CRCI) in breast cancer significantly impacts patients’ quality of life and has become a research topic of growing concern in the field of oncology nursing. However, the current research landscape, hotspots, and trends in this area lack systematic visualization. This study aims to conduct a visual analysis of CRCI research in breast cancer using CiteSpace software, to understand its research status, hotspots, and trends, and to provide new insights for future nursing practice. Methods: Relevant literature on breast cancer CRCI was retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) databases for the period from January 1, 2000 to October 31, 2025. A visualization analysis was performed to review the annual publication trends, summarize the collaborative network characteristics of authors and institutions, and analyze the distribution of research themes reflected by keyword co-occurrence and clustering. Results: A total of 141 Chinese articles from CNKI and 517 English articles from WOS were included. The annual publication volume in this field exhibited a cyclical fluctuation trend. Internationally, stable collaborative teams have been formed, with relatively close inter-institutional cooperation. Chemotherapy was identified as the most critical influencing factor, while cognitive impairment and memory decline were the most common clinical manifestations of CRCI. Conclusion: Chemotherapy remains the core influencing factor, with cognitive impairment, memory decline, and quality of life being the most common clinical presentations and outcome indicators. While stable research collaboration networks have been established internationally—especially in North America and Europe—domestic institutional and author collaboration networks in China remain sparse, and a stable core author group has yet to be formed. Cross-regional collaborative networks remain weak. Based on these findings, this study proposes that future research should further strengthen in-depth collaboration across countries, institutions, and scholars. The analysis suggests that non-pharmacological interventions, cognitive training, psychosocial support, and personalized care models will become the research frontiers and hotspots in this field, providing a clear direction for clinical nursing practice and future research on breast cancer CRCI.