针刺治疗卒中后抑郁的机制研究进展
Research Progress on the Mechanisms of Acupuncture in the Treatment of Post-Stroke Depression
DOI: 10.12677/acrem.2026.144055, PDF,   
作者: 曹必可：黑龙江中医药大学研究生院，黑龙江 哈尔滨；陈英华：黑龙江中医药大学附属第一医院针灸五科，黑龙江 哈尔滨
关键词: 卒中后抑郁；针刺；细胞凋亡；自噬；线粒体；氧化应激；神经炎症；综述；Post-Stroke Depression； Acupuncture； Apoptosis； Autophagy； Mitochondria； Oxidative Stress； Neuroinflammation； Review
摘要: 卒中后抑郁(post-stroke depression, PSD)是脑卒中后最常见的神经精神并发症，严重影响患者神经功能康复及预后。针刺作为传统中医疗法，在PSD治疗中展现出多靶点调控优势。本文聚焦针刺治疗PSD的基础研究机制，重点阐述针刺通过抑制神经细胞凋亡与自噬、改善线粒体功能与氧化应激损伤、调节神经炎症反应等途径发挥抗抑郁作用的分子机制，以期为针刺治疗PSD的深入研究提供理论参考。
Abstract: Post-stroke depression is the most common neuropsychiatric complication after stroke, which seriously affects the neurological rehabilitation and prognosis of patients. As a traditional Chinese medicine therapy, acupuncture shows the advantages of multi-target regulation in the treatment of PSD. This article focuses on the basic research mechanism of acupuncture in the treatment of PSD, and focuses on the molecular mechanism of acupuncture’s antidepressant effect by inhibiting neuronal apoptosis and autophagy, improving mitochondrial function and oxidative stress injury, and regulating neuroinflammatory response, in order to provide a theoretical reference for the in-depth study of acupuncture in the treatment of PSD.
文章引用：曹必可, 陈英华. 针刺治疗卒中后抑郁的机制研究进展[J]. 亚洲急诊医学病例研究, 2026, 14(4): 433-437. https://doi.org/10.12677/acrem.2026.144055

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