二苯乙烯C-糖苷和O-糖苷的合成研究进展
Research Progress in the Synthesis of C-Glycosides and O-Glycosides of Styrene
DOI: 10.12677/jocr.2026.143038, PDF,   
作者: 王丽丽, 袁嘉遥, 李文玲:兰州交通大学化学化工学院,甘肃 兰州
关键词: 二苯乙烯;C-糖苷;O-糖苷;溶解度;合成;Stilbenes; C-Glycosides; O-Glycosides; Solubility; Synthesis
摘要: 二苯乙烯类化合物具有丰富多样的生物活性,在人类生活中具有潜在的药用价值,它们的合成和应用已被广泛研究,然而,这些二苯乙烯类化合物在水中的不溶性极大限制了它们的生物利用度和药物开发。因此,在二苯乙烯单体上引入糖基有助于增加溶解度,降低毒性。本文归纳总结了近年来二苯乙烯0-糖苷和C-糖苷化合物的化学合成以及生物合成等方面的研究进展,并对未来该邻域的发展进行了展望。
Abstract: Stilbene compounds exhibit a wide range of biological activities and possess potential medicinal value for human applications, and their synthesis and application have been extensively investigated. Nevertheless, the poor water solubility of stilbenes severely restricts their bioavailability and pharmaceutical development. Accordingly, glycosylation modification on stilbene monomers can improve their aqueous solubility and reduce toxicity. This paper summarizes the recent advances in chemical synthesis and biosynthesis of stilbene O-glycosides and C-glycosides, and prospects the future development of this field.
文章引用:王丽丽, 袁嘉遥, 李文玲. 二苯乙烯C-糖苷和O-糖苷的合成研究进展[J]. 有机化学研究, 2026, 14(3): 440-450. https://doi.org/10.12677/jocr.2026.143038

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