运脾散联合莫沙必利治疗脾胃虚寒型功能性消化不良的临床疗效观察

Clinical Evaluation of the Efficacy of Yun Pi Powder Acupoint Application Combined with Mosapride in Treating Functional Dyspepsia of the Spleen-Stomach Deficiency Cold Pattern

摘要: 目的：探究运脾散穴位贴敷联合莫沙必利治疗脾胃虚寒型功能性消化不良(FD)的临床疗效。方法：选取2025年1月至2026年1月期间上海市崇明区港西社区卫生服务中心以及上海中医药大学附属龙华医院收治的脾胃虚寒型FD患者68例，按随机数字表法分为治疗组(n = 35)和对照组(n = 33)。对照组给予莫沙必利口服治疗，治疗组在对照组基础上加用运脾散穴位贴敷。两组均连续治疗8周，比较两组临床疗效、中医证候积分、生活质量评分等。结果：治疗组总有效率为88.57%，显著高于对照组的66.67% (P < 0.05)。治疗后，两组中医证候积分均较治疗前显著降低(P < 0.01)，且治疗组降低幅度更大(P < 0.05)。治疗组在胃痛、纳呆及便溏、疲乏等次症方面改善均优于对照组(P < 0.05)，而对胃胀、嗳气两组间无统计学差异。两组NDSI评分治疗后较治疗前降低(P < 0.05)，NDLQI评分较治疗前升高(P < 0.05)，且NDSI评分治疗组低于对照组(P < 0.05)，而NDLQI评分治疗组高于对照组(P < 0.05)。两组均未发生严重不良反应，仅见轻微局部皮肤反应。结论：初步结果表明，运脾散穴位贴敷联合莫沙必利治疗脾胃虚寒型FD可进一步改善临床症状及生活质量，且安全性良好，但需更大样本、多中心研究进一步验证。

Abstract: Objective: To observe the clinical efficacy of Yunpi Powder acupoint application combined with Mosapride in the treatment of functional dyspepsia (FD) of the spleen-stomach deficiency cold pattern. Methods: A total of 68 patients with FD of the spleen-stomach deficiency cold pattern, admitted to the Gangxi Community Health Service Center in Chongming District, Shanghai, and Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine between January 2025 and January 2026, were selected. They were divided into a treatment group (n = 35) and a control group (n = 33) according to a random number table. The control group was treated with oral Mosapride, while the treatment group received Yunpi Powder acupoint application in addition to the treatment given to the control group. Both groups were treated continuously for 8 weeks. The clinical efficacy, TCM syndrome scores, and quality of life scores were compared between the two groups. Results: The total effective rate of the treatment group was 88.57%, which was significantly higher than the 66.67% of the control group (P < 0.05). After treatment, the TCM syndrome scores of both groups were significantly lower than before treatment (P < 0.01), and the reduction in the treatment group was greater (P < 0.05). The treatment group was superior to the control group in improving secondary symptoms such as stomach pain, poor appetite, loose stools, and fatigue (P < 0.05), while there was no statistically significant difference between the two groups in terms of stomach distension and belching. The NDSI scores of both groups decreased after treatment compared to before treatment (P < 0.05), and the NDLQI scores increased compared to before treatment (P < 0.05). Furthermore, the NDSI score in the treatment group was lower than that in the control group (P < 0.05), while the NDLQI score was higher (P < 0.05). No serious adverse reactions occurred in either group, with only mild local skin reactions observed. Conclusion: Preliminary results suggest that Yunpi Powder acupoint application combined with Mosapride may further improve clinical symptoms and quality of life in patients with FD of the spleen-stomach deficiency cold pattern, with good safety. However, larger multicenter studies are needed to further validate these findings.