基于中医传承辅助平台探讨中医治疗特发性膜性肾病用药规律

Exploration of Medication Rules in Traditional Chinese Medicine for Idiopathic Membranous Nephropathy Based on the Traditional Chinese Medicine Inheritance Support Platform

摘要: 目的：基于中医传承辅助平台V2.5版，分析中国知网(CNKI)中当代中医药治疗特发性膜性肾病组方规律。方法：通过收集CNKI中采用中医方剂治疗特发性膜性肾病的相关文献，运用中医传承辅助平台V2.5软件建立数据库，分析并总结特发性膜性肾病方药特点。结果：CNKI中治疗特发性膜性肾病方剂共78首，包含中药347种，分析出黄芪、茯苓、当归使用频率较高，药性以平、温、寒性药为主；五味以甘、苦、辛、酸味为主；主要归脾、肝、肾；得常用药对及配伍规律为黄芪–茯苓、黄芪–当归、党参–黄芪为常用药物组，演化得到新处方5首。结论：通过中医组方以甘温健脾、固肾摄精为主。可为临床治疗和后续研究提供参考。

Abstract: Objective: Based on the Traditional Chinese Medicine Inheritance Support Platform (V2.5), this study analyzes the formulation rules of contemporary traditional Chinese medicine for idiopathic membranous nephropathy in the China National Knowledge Infrastructure (CNKI). Methods: Relevant literature on traditional Chinese herbal prescriptions for idiopathic membranous nephropathy was collected from CNKI. A database was established using the Traditional Chinese Medicine Inheritance Support Platform (V2.5) to analyze and summarize the characteristics of herbal prescriptions for idiopathic membranous nephropathy. Results: A total of 78 prescriptions for idiopathic membranous nephropathy were collected from CNKI, involving 347 Chinese medicinal herbs. Astragali Radix, Poria and Angelicae Sinensis Radix were used relatively frequently. The medicinal properties were mainly neutral, warm and cold. The dominant flavors were sweet, bitter, pungent and sour. The herbs mainly act on the spleen, liver and kidney meridians. The frequently used herb pairs and compatibility rules included Astragali Radix-Poria, Astragali Radix-Angelicae Sinensis Radix, and Codonopsis Radix-Astragali Radix. Five new prescriptions were obtained through evolution. Conclusion: The TCM prescriptions are mainly characterized by invigorating the spleen with sweet-warm herbs, consolidating the kidney and securing essence. The findings can provide references for clinical treatment and further research.