空间–频率域分层特征增强的乳腺超声图像分割
Spatial-Frequency Domain Hierarchical Feature Enhancement for Breast Ultrasound Image Segmentation
摘要: 乳腺超声图像分割是计算机辅助诊断系统的关键环节,但斑点噪声干扰与病灶边界模糊给精确分割带来了严峻挑战。现有方法多采用统一策略处理跳跃连接中的多层级特征,忽视了浅层特征噪声敏感与深层特征定位模糊的本质差异。针对上述问题,提出一种空间–频率域分层特征增强的轻量化分割网络SFH-Net (Spatial-Frequency Hierarchical Network)。首先,设计交替双路径编码器,通过标准卷积与深度可分离卷积的交替组合并引入空洞卷积扩展感受野,在保证特征提取能力的同时有效控制参数规模;其次,提出分层跳跃连接策略,对浅层特征引入自适应频域滤波模块以抑制斑点噪声,对深层特征采用坐标注意力机制增强空间定位能力。在BUSI和UDIAT两个公开数据集上的实验表明,SFH-Net以仅13.12 M的参数量分别取得了78.73%和85.15%的Dice系数,所提出方法能够在保持较低模型复杂度的同时实现有效的病灶分割。
Abstract: Breast ultrasound image segmentation is a crucial component of computer-aided diagnosis systems, yet speckle noise interference and blurred lesion boundaries pose severe challenges to accurate segmentation. Existing methods mostly adopt a unified strategy to process multi-level features in skip connections, ignoring the essential differences between shallow features that are sensitive to noise and deep features with imprecise localization, and also underutilize frequency domain information. To address these issues, we propose a lightweight segmentation network named SFH-Net with spatial-frequency domain hierarchical feature enhancement. First, an alternating dual-path encoder is designed: the alternating combination of standard convolution and depthwise separable convolution, combined with the introduction of atrous convolution to expand the receptive field, effectively controls the parameter scale while ensuring the feature extraction capability. Second, a hierarchical skip connection strategy is proposed: an adaptive frequency domain filtering module is introduced for shallow features to suppress speckle noise, and the coordinate attention mechanism is adopted for deep features to enhance spatial localization ability. Experiments on two public datasets (BUSI and UDIAT) demonstrate that SFH-Net achieves Dice coefficients of 78.73% and 85.15% with only 13.12 million parameters, the proposed method can achieve effective lesion segmentation while maintaining low model complexity.
文章引用:蔡嘉丽, 李露希, 钟森洁, 李春艳. 空间–频率域分层特征增强的乳腺超声图像分割[J]. 图像与信号处理, 2026, 15(4): 505-516. https://doi.org/10.12677/jisp.2026.154045

参考文献

[1] Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263.
https://doi.org/10.3322/caac.21834
[2] Berg, W.A. (2008) Combined Screening with Ultrasound and Mammography vs Mammography Alone in Women at Elevated Risk of Breast Cancer. JAMA, 299, 2151-2163.
https://doi.org/10.1001/jama.299.18.2151
[3] Loizou, C.P. and Pattichis, C.S. (2015) Despeckle Filtering for Ultrasound Imaging and Video. 2nd Edition, Morgan & Claypool Publishers.
[4] Ronneberger, O., Fischer, P. and Brox, T. (2015) U-Net: Convolutional Networks for Biomedical Image Segmentation. In: Navab, N., Hornegger, J., Wells, W. and Frangi, A., Eds., Medical Image Computing and Computer-Assisted Intervention—MICCAI 2015, Springer, 234-241.
https://doi.org/10.1007/978-3-319-24574-4_28
[5] Zhou, Z., Rahman Siddiquee, M.M., Tajbakhsh, N. and Liang, J. (2018) UNet++: A Nested U-Net Architecture for Medical Image Segmentation. In: Stoyanov, D., et al., Eds., Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support, Springer, 3-11.
https://doi.org/10.1007/978-3-030-00889-5_1
[6] Huang, H., Lin, L., Tong, R., Hu, H., Zhang, Q., Iwamoto, Y., et al. (2020) UNet 3+: A Full-Scale Connected Unet for Medical Image Segmentation. ICASSP 2020—2020 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 4-8 May 2020, 1055-1059.
https://doi.org/10.1109/icassp40776.2020.9053405
[7] Oktay, O., Schlemper, J., Le Folgoc, L., et al. (2018) Attention U-Net: Learning Where to Look for the Pancreas. arXiv: 1804.03999
[8] Zhang, Z., Liu, Q. and Wang, Y. (2018) Road Extraction by Deep Residual U-Net. IEEE Geoscience and Remote Sensing Letters, 15, 749-753.
https://doi.org/10.1109/lgrs.2018.2802944
[9] Gu, Z., Cheng, J., Fu, H., Zhou, K., Hao, H., Zhao, Y., et al. (2019) Ce-Net: Context Encoder Network for 2D Medical Image Segmentation. IEEE Transactions on Medical Imaging, 38, 2281-2292.
https://doi.org/10.1109/tmi.2019.2903562
[10] Chen, J., Lu, Y., Yu, Q., et al. (2021) TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation. arXiv: 2102.04306
[11] Cao, H., Wang, Y., Chen, J., Jiang, D., Zhang, X., Tian, Q., et al. (2023) Swin-Unet: UNET-Like Pure Transformer for Medical Image Segmentation. In: Karlinsky, L., Michaeli, T. and Nishino, K., Eds., Computer Vision—ECCV 2022 Workshops, Springer, 205-218.
https://doi.org/10.1007/978-3-031-25066-8_9
[12] Wang, H., Cao, P., Wang, J. and Zaiane, O.R. (2022) Uctransnet: Rethinking the Skip Connections in U-Net from a Channel-Wise Perspective with Transformer. Proceedings of the AAAI Conference on Artificial Intelligence, 36, 2441-2449.
https://doi.org/10.1609/aaai.v36i3.20144
[13] Tang, F., Wang, L., Ning, C., Xian, M. and Ding, J. (2023) CMU-Net: A Strong Convmixer-Based Medical Ultrasound Image Segmentation Network. 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), Cartagena, 18-21 April 2023, 1-5.
https://doi.org/10.1109/isbi53787.2023.10230609
[14] Xu, K., Qin, M., Sun, F., Wang, Y., Chen, Y. and Ren, F. (2020) Learning in the Frequency Domain. 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 14-19 June 2020, 1740-1749.
https://doi.org/10.1109/cvpr42600.2020.00181
[15] 陈柯炎, 刘巧红, 韩啸翔, 等. 结合频域先验和特征增强的心脏图像分割方法[J]. 激光与光电子学进展, 2024, 61(10): 367-376.
[16] 刘峰. 基于信息迁移的半监督心脏磁共振图像分割[D]: [硕士学位论文]. 烟台: 烟台大学, 2025.
[17] Howard, A.G., Zhu, M., Chen, B., et al. (2017) MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications. arXiv: 1704.04861
[18] 杨军, 张金影, 康玥. 基于自注意力机制的高分遥感影像语义分割[J]. 哈尔滨工程大学学报, 2025, 46(2): 344-354.
[19] He, K., Zhang, X., Ren, S. and Sun, J. (2016) Deep Residual Learning for Image Recognition. 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), Las Vegas, NV, 27-30 June 2016, 770-778.
https://doi.org/10.1109/CVPR.2016.90
[20] 陈諝劼. 基于改进U-Net的医学影像分割方法研究[D]: [硕士学位论文]. 广州: 广东财经大学, 2025.
[21] Joel, T. and Sivakumar, R. (2018) An Extensive Review on Despeckling of Medical Ultrasound Images Using Various Transformation Techniques. Applied Acoustics, 138, 18-27.
https://doi.org/10.1016/j.apacoust.2018.03.023
[22] Esakkirajan, S., Vimalraj, C.T., Muhammed, R. and Subramanian, G. (2013) Adaptive Wavelet Packet-Based De-Speckling of Ultrasound Images with Bilateral Filter. Ultrasound in Medicine & Biology, 39, 2463-2476.
https://doi.org/10.1016/j.ultrasmedbio.2013.07.009
[23] Hou, Q., Zhou, D. and Feng, J. (2021) Coordinate Attention for Efficient Mobile Network Design. 2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), 19-25 June 2021, 13713-13722.
https://doi.org/10.1109/cvpr46437.2021.01350
[24] Wu, H., Chen, S., Chen, G., Wang, W., Lei, B. and Wen, Z. (2022) Fat-Net: Feature Adaptive Transformers for Automated Skin Lesion Segmentation. Medical Image Analysis, 76, Article ID: 102327.
https://doi.org/10.1016/j.media.2021.102327
[25] Ibtehaz, N. and Kihara, D. (2023) ACC-UNet: A Completely Convolutional UNet Model for the 2020s. In: Greenspan, H., et al., Medical Image Computing and Computer Assisted Intervention (MICCAI 2023), Springer, 692-702.
https://doi.org/10.1007/978-3-031-43898-1_66
[26] Zhou, Z.H., He, A., Wu, Y., Yao, R., Xie, X. and Li, T. (2024) Spatial-Frequency Dual Domain Attention Network for Medical Image Segmentation. arXiv: 2406.07952v2
[27] Li, H., Ren, Z., Zhu, G., Liang, Y., Cui, H., Wang, C., et al. (2025) Enhancing Medical Image Segmentation with MA-UNet: A Multi-Scale Attention Framework. The Visual Computer, 41, 6103-6120.
https://doi.org/10.1007/s00371-024-03774-9