基于“驱邪外出”理论的银翘散加减方对病毒肺炎无症状感染者病毒清除时效的影响

Effects of Modified Yinqiao Powder Based on the Theory of “Expelling Pathogens Outward” on Virus-Clearance Time-Effect in Asymptomatic Patients with Viral Pneumonia

摘要: 目的基于“驱邪外出”中医理论，探析银翘散加减方联合西医常规治疗病毒肺炎无症状感染者的效果与价值。方法纳入2024年1月~2025年6月期间本院收治86例病毒肺炎无症状感染者，依据治疗方案不同进行分组，对照组43例给予西医常规治疗，观察组43例联合银翘散加减方治疗，比较两组症状改善情况、病毒清除时效、炎症因子水平、淋巴细胞亚群水平、肺炎病灶吸收情况。结果观察组症状改善总有效率更高(P < 0.05)。观察组病毒清除时效更短(P < 0.05)。治疗后，观察组细胞介素-6、肿瘤坏死因子-α水平均更低，白细胞介素-10更高(P < 0.05)。治疗后，观察组CD3⁺、CD4⁺更高，CD8⁺更低(P < 0.05)。观察组肺炎病灶完全吸收率更高(P < 0.05)。结论基于“驱邪外出”理论的银翘散加减方能够显著缩短病毒肺炎无症状感染者的病毒清除时效，其作用机制可能与驱邪透表、调节炎性–免疫稳态、促进病毒从体内有序清除有关，体现了“给邪以出路”的中医治疗思想。

Abstract: Objective: To explore the efficacy and value of modified Yinqiao Powder combined with conventional Western medicine in the treatment of asymptomatic patients with viral pneumonia based on the traditional Chinese medicine theory of “expelling pathogens outward”. Methods: A total of 86 asymptomatic patients with viral pneumonia admitted to our hospital from January 2024 to June 2025 were enrolled and divided into groups according to different treatment regimens. The control group (43 cases) received conventional Western-medicine treatment, while the observation group (43 cases) was additionally treated with modified Yinqiao Powder. The symptom improvement, virus-clearance time-effect, levels of inflammatory factors, lymphocyte subsets, and absorption of pulmonary lesions were compared between the two groups. Results: The observation group achieved a higher overall effective rate of symptom improvement (P < 0.05). The virus-clearance time-effect was significantly shorter in the observation group (P < 0.05). After treatment, the levels of interleukin-6 and tumor necrosis factor-α were lower, whereas interleukin-10 was higher in the observation group (P < 0.05). Post-treatment CD3⁺ and CD4⁺ counts were higher and CD8⁺ count was lower in the observation group (P < 0.05). The complete absorption rate of pulmonary lesions was higher in the observation group (P < 0.05). Conclusion: Modified Yinqiao Powder based on the theory of “expelling pathogens outward” can markedly shorten the virus-clearance time-effect in asymptomatic patients with viral pneumonia. Its mechanism may be related to expelling pathogens through the exterior, regulating inflammatory-immune homeostasis and facilitating orderly viral clearance from the body, which embodies the TCM therapeutic idea of “providing outlets for pathogens”.