天然黄酮醇类化合物干预白癜风的作用机制及研究进展
Mechanism and Research Progress of Natural Flavonol Compounds in the Intervention of Vitiligo
DOI: 10.12677/acm.2026.16103435, PDF,    科研立项经费支持
作者: 宋凯歌：黑龙江中医药大学第一临床学院，黑龙江 哈尔滨；王远红*：黑龙江中医药大学附属第一医院，黑龙江 哈尔滨
关键词: 白癜风；黄酮醇类化合物；作用机制；中药复方；Vitiligo； Flavonol Compounds； Mechanism of Action； Traditional Chinese Medicine Compound
摘要: 白癜风是一种色素脱失性皮肤病，与患者自身免疫反应破坏黑色素细胞、氧化应激等诸多因素相关。患病严重影响患者身心健康。黄酮类化合物包括槲皮素、山奈酚、杨梅素、桑色素、高良姜素、异鼠李素等。其天然活性成分在白癜风治疗中展现出巨大潜力，因其具有调节氧化应激、抑制自身免疫及促进黑素细胞存活的能力，能够在白癜风的临床治疗中发挥积极作用。本文通过对中药黄酮醇类化合物干预白癜风的机制研究及中药复方中的黄酮醇类化合物进行综述，以期为开发安全有效且机制明确的相关药物提供参考。
Abstract: Vitiligo is a depigmented skin disease, which is related to many factors such as the destruction of melanocytes and oxidative stress by the patient’s autoimmune response. The disease seriously affects the physical and mental health of patients. Flavonoids include quercetin, kaempferol, myricetin, morin, galangin, isorhamnetin, etc. Its natural active ingredients show great potential in the treatment of vitiligo. Because of its ability to regulate oxidative stress, inhibit autoimmunity and promote the survival of melanocytes, it can play an active role in the clinical treatment of vitiligo. In this paper, the mechanism of traditional Chinese medicine flavonol compounds in the intervention of vitiligo and the flavonol compounds in traditional Chinese medicine compound were reviewed in order to provide reference for the development of safe and effective related drugs with clear mechanism.
文章引用：宋凯歌, 王远红. 天然黄酮醇类化合物干预白癜风的作用机制及研究进展[J]. 临床医学进展, 2026, 16(10): 1289-1297. https://doi.org/10.12677/acm.2026.16103435

参考文献

[1] 中国中西医结合学会皮肤性病专业委员会色素病学组. 白癜风2024诊疗共识[J]. 中华皮肤科杂志, 2021, 54(2): 105-109.
http://www.pifukezazhi.com/CN/10.35541/cjd.20200785
[2] Krüger, C. and Schallreuter, K.U. (2012) A Review of the Worldwide Prevalence of Vitiligo in Children/Adolescents and Adults. International Journal of Dermatology, 51, 1206-1212.
https://doi.org/10.1111/j.1365-4632.2011.05377.x
[3] 尹瑞文, 胡璘媛, 赵丽娟, 等. 皮肤病患者心理状态研究与心理干预治疗进展[J]. 黑龙江医学, 2017, 41(5): 476-479.
[4] Lemanowicz, J., Gawlińska, K., Jaskulska, I., Jaskulski, D. and Sar, M. (2025) Flavonoids in Plants and Human Health: From Biosynthesis to Neurodevelopmental and Neurodegenerative Disorders. Molecules, 31, Article 66.
https://doi.org/10.3390/molecules31010066
[5] Panche, A.N., Diwan, A.D. and Chandra, S.R. (2016) Flavonoids: An Overview. Journal of Nutritional Science, 5, e47.
https://doi.org/10.1017/jns.2016.41
[6] Drețcanu, G., Știrbu, I., Leoplold, N., Cruceriu, D., Danciu, C., Stănilă, A., et al. (2022) Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review. Plants, 11, Article 1117.
https://doi.org/10.3390/plants11091117
[7] 王璐, 王蓉, 蒯海敏, 等. 天然黄酮类化合物皮肤保护作用研究进展[J]. 海峡药学, 2025, 37(10): 1-4.
[8] Yu, T., Wu, Y. and Lu, Z. (2024) Research Progress of Vitiligo Repigmentation: From Oxidative Stress to Autoimmunity. Cellular and Molecular Biology, 70, 147-151.
https://doi.org/10.14715/cmb/2024.70.4.23
[9] Upadhya, S., Andrade, M.J., Shukla, V., Rao, R. and Satyamoorthy, K. (2025) Genetic and Immune Dysregulation in Vitiligo: Insights into Autoimmune Mechanisms and Disease Pathogenesis. Autoimmunity Reviews, 24, Article 103841.
https://doi.org/10.1016/j.autrev.2025.103841
[10] Przybylski, T., Czerniel, J., Dobrosielski, J. and Stawny, M. (2025) Flavonol Technology: From the Compounds’ Chemistry to Clinical Research. Molecules, 30, Article 3113.
https://doi.org/10.3390/molecules30153113
[11] Shabir, I., Kumar Pandey, V., Shams, R., Dar, A.H., Dash, K.K., Khan, S.A., et al. (2022) Promising Bioactive Properties of Quercetin for Potential Food Applications and Health Benefits: A Review. Frontiers in Nutrition, 9, Article ID: 999752.
https://doi.org/10.3389/fnut.2022.999752
[12] Aghababaei, F. and Hadidi, M. (2023) Recent Advances in Potential Health Benefits of Quercetin. Pharmaceuticals, 16, Article 1020.
https://doi.org/10.3390/ph16071020
[13] 李乐兴, 戴汉川. 槲皮素对细胞死亡通路的多方面调控作用: 凋亡、铁死亡、焦亡与自噬[J]. 中国科学: 生命科学, 2026, 56(3): 545-554.
[14] Xu, D., Hu, M., Wang, Y. and Cui, Y. (2019) Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application. Molecules, 24, Article 1123.
https://doi.org/10.3390/molecules24061123
[15] 杨逸轩, 杜炎远, 俞天辰, 等. 中药黄酮类化合物干预白癜风作用机制研究进展[J]. 中成药, 2025, 47(6): 1931-1937.
[16] Yamauchi, K., Mitsunaga, T., Inagaki, M. and Suzuki, T. (2014) Synthesized Quercetin Derivatives Stimulate Melanogenesis in B16 Melanoma Cells by Influencing the Expression of Melanin Biosynthesis Proteins MITF and P38 Mapk. Bioorganic & Medicinal Chemistry, 22, 3331-3340.
https://doi.org/10.1016/j.bmc.2014.04.053
[17] Okselni, T., Septama, A.W., Juliadmi, D., Dewi, R.T., Angelina, M., Yuliani, T., et al. (2025) Quercetin as a Therapeutic Agent for Skin Problems: A Systematic Review and Meta-Analysis on Antioxidant Effects, Oxidative Stress, Inflammation, Wound Healing, Hyperpigmentation, Aging, and Skin Cancer. Naunyn-Schmiedeberg’s Archives of Pharmacology, 398, 5011-5055.
https://doi.org/10.1007/s00210-024-03722-3
[18] Chaiprasongsuk, A. and Panich, U. (2022) Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2. Frontiers in Pharmacology, 13, Article ID: 823881.
https://doi.org/10.3389/fphar.2022.823881
[19] Rajnochová Svobodová, A., Ryšavá, A., Čížková, K., Roubalová, L., Ulrichová, J., Vrba, J., et al. (2022) Effect of the Flavonoids Quercetin and Taxifolin on UVA-Induced Damage to Human Primary Skin Keratinocytes and Fibroblasts. Photochemical & Photobiological Sciences, 21, 59-75.
https://doi.org/10.1007/s43630-021-00140-9
[20] Liu, W., Hu, M., Cao, F. and Jin, S. (2025) Polyphenols and Exercise in Autophagy Regulation: Potential Benefits for Cancer Management and Healthspan. Frontiers in Nutrition, 12, Article ID: 1618813.
https://doi.org/10.3389/fnut.2025.1618813
[21] Guan, C., Xu, W., Hong, W., Zhou, M., Lin, F., Fu, L., et al. (2015) Quercetin Attenuates the Effects of H2O2 on Endoplasmic Reticulum Morphology and Tyrosinase Export from the Endoplasmic Reticulum in Melanocytes. Molecular Medicine Reports, 11, 4285-4290.
https://doi.org/10.3892/mmr.2015.3242
[22] Chen, J., Zhong, H., Huang, Z., Chen, X., You, J. and Zou, T. (2023) A Critical Review of Kaempferol in Intestinal Health and Diseases. Antioxidants, 12, Article 1642.
https://doi.org/10.3390/antiox12081642
[23] Calderón-Montaño, J.M., Burgos-Morón, E., Pérez-Guerrero, C., et al. (2011) A Review on the Dietary Flavonoid Kaempferol. Mini-Reviews in Medicinal Chemistry, 11, 298-344.
[24] Li, J., Song, Y. and Yang, M. (2025) An Investigation into the Mechanism for Kaempferol Improving Melanocyte Death Based on Network Pharmacology and Experimental Verification. Scientific Reports, 15, Article No. 8616.
https://doi.org/10.1038/s41598-025-91905-0
[25] Xu, X., Lei, Z., Hu, W., Wang, H., Xiang, F., Ding, Y., et al. (2026) Kaempferol Protects Melanocytes from Ferroptosis by Modulating the NF-κB/PTGS2 Signaling Axis in Vitiligo. Apoptosis, 31, Article No. 124.
https://doi.org/10.1007/s10495-026-02334-x
[26] 邹雪莲, 胡雯, 雷子贤, 等. 山奈酚减轻人角质形成细胞氧化应激损伤[J]. 基础医学与临床, 2021, 41(8): 1103-1108.
[27] 彭怡, 李伟佳, 黄巧, 等. 基于网络药理学和分子对接探讨蒺藜治疗白癜风的作用机制[J]. 皮肤性病诊疗学杂志, 2024, 31(3): 180-189.
[28] Devi, A., Kabra, A., Saeedan, A.S. and Ansari, M.N. (2025) Exploring Myricetin: A Comprehensive Review of Its Pharmacological Potential, Formulation Strategies, and Clinical Outlook. Naunyn-Schmiedeberg’s Archives of Pharmacology, 399, 3189-3225.
https://doi.org/10.1007/s00210-025-04648-0
[29] Semwal, D., Semwal, R., Combrinck, S. and Viljoen, A. (2016) Myricetin: A Dietary Molecule with Diverse Biological Activities. Nutrients, 8, Article 90.
https://doi.org/10.3390/nu8020090
[30] 王潞, 周云英. 杨梅素抗感染、抗炎及抗氧化活性研究进展[J]. 中草药, 2019, 50(3): 778-784.
[31] 赵丽, 徐淑萍, 李宗阳, 等. 杨梅素及其类似物抗氧化与乙酰胆碱酯酶抑制活性研究[J]. 食品工业科技, 2012, 33(1): 56-58+62.
[32] Almatroodi, S.A. and Rahmani, A.H. (2025) Unlocking the Pharmacological Potential of Myricetin against Various Pathogenesis. International Journal of Molecular Sciences, 26, Article 4188.
https://doi.org/10.3390/ijms26094188
[33] Kandasamy, N. and Ashokkumar, N. (2013) Myricetin Modulates Streptozotocin-Cadmium Induced Oxidative Stress in Long Term Experimental Diabetic Nephrotoxic Rats. Journal of Functional Foods, 5, 1466-1477.
https://doi.org/10.1016/j.jff.2013.06.004
[34] Cao, J., Jia, Z., He, K., Song, B., Chao, L., Wang, B., et al. (2026) Myricetin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Pyroptosis via Activation of the Nrf2/HO-1/NQO1 Signaling Pathway. Archives of Biochemistry and Biophysics, 782, Article 110848.
https://doi.org/10.1016/j.abb.2026.110848
[35] Nath, R., Manna, S., Panda, S., Maity, A., Bandyopadhyay, K., Das, A., et al. (2024) Flavonoid Based Development of Synthetic Drugs: Chemistry and Biological Activities. Chemistry & Biodiversity, 22, e202401899.
https://doi.org/10.1002/cbdv.202401899
[36] 赖瑞联, 吴如健, 赖钟雄. 植物类黄酮的分类、药理活性及其生物合成调控研究进展[J]. 东南园艺, 2024, 12(2): 81-99.
[37] 杨诗魁, 欧隽滢, 黄才欢, 等. 4种黄酮类化合物对黄嘌呤氧化酶的抑制作用及机制[J]. 食品科学, 2026, 47(17): 10-18.
[38] Zhang, H., Zheng, W., Feng, X., Yang, F., Qin, H., Wu, S., et al. (2019) Nrf2-ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of Fisetin. Molecules, 24, Article 708.
https://doi.org/10.3390/molecules24040708
[39] Mirza, M.A., Padhi, S., Mohapatra, S., Mahmood, S. and Iqbal, Z. (2025) Fisetin from Dietary Supplement to a Drug Candidate: An Assessment of Potential. Current Pharmaceutical Biotechnology, 26, 1143-1158.
https://doi.org/10.2174/0113892010304479240415074928
[40] Yang, W., Tian, Z., Yang, H., Feng, Z., Sun, J., Jiang, H., et al. (2019) Fisetin Improves Lead-Induced Neuroinflammation, Apoptosis and Synaptic Dysfunction in Mice Associated with the AMPK/SIRT1 and Autophagy Pathway. Food and Chemical Toxicology, 134, Article 110824.
https://doi.org/10.1016/j.fct.2019.110824
[41] Ei, Z.Z., Racha, S., Zou, H. and Chanvorachote, P. (2025) Mechanistic Insights into Anti-Melanogenic Effects of Fisetin: PKCα-Induced Β-Catenin Degradation, ERK/MITF Inhibition, and Direct Tyrosinase Suppression. International Journal of Molecular Sciences, 26, Article 11739.
https://doi.org/10.3390/ijms262311739
[42] 植天道, 黄齐慧. 桑色素的研究进展[J]. 中国中医药现代远程教育, 2009, 7(3): 112-115.
[43] Rajput, S.A., Wang, X. and Yan, H. (2021) Morin Hydrate: A Comprehensive Review on Novel Natural Dietary Bioactive Compound with Versatile Biological and Pharmacological Potential. Biomedicine & Pharmacotherapy, 138, Article 111511.
https://doi.org/10.1016/j.biopha.2021.111511
[44] Shin, S., Ko, J., Kim, M., Song, N. and Park, K. (2021) Morin Induces Melanogenesis via Activation of MAPK Signaling Pathways in B16F10 Mouse Melanoma Cells. Molecules, 26, Article 2150.
https://doi.org/10.3390/molecules26082150
[45] Anna, H., Balaji, P., Kannan, P., N, M.P., Warrier, S. and Ramasamy, M. (2025) Targeting V347G Variant in NLRP1 Protein Causing Vitiligo with Morin and Kaempferol Flavonoids: A Computational Pipeline. Chemistry Select, 10, e02132.
https://doi.org/10.1002/slct.202502132
[46] Wang, H., Chen, L., Yang, B., Du, J., Chen, L., Li, Y., et al. (2023) Structures, Sources, Identification/Quantification Methods, Health Benefits, Bioaccessibility, and Products of Isorhamnetin Glycosides as Phytonutrients. Nutrients, 15, 1947.
https://doi.org/10.3390/nu15081947
[47] Gong, G., Guan, Y., Zhang, Z., Rahman, K., Wang, S., Zhou, S., et al. (2020) Isorhamnetin: A Review of Pharmacological Effects. Biomedicine & Pharmacotherapy, 128, Article 110301.
https://doi.org/10.1016/j.biopha.2020.110301
[48] González-Arceo, M., Gomez-Lopez, I., Carr-Ugarte, H., Eseberri, I., González, M., Cano, M.P., et al. (2022) Anti-Obesity Effects of Isorhamnetin and Isorhamnetin Conjugates. International Journal of Molecular Sciences, 24, Article 299.
https://doi.org/10.3390/ijms24010299
[49] 陈萍, 薛佩芸, 梁馨月, 等. 银杏叶标准汤质量评价研究及高效液相色谱指纹图谱的建立[J]. 中国药业, 2019, 28(12): 17-20.
[50] 丁金, 铁芳芳, 王洪伦. HPLC快速测定沙棘叶中的苯丙素与黄酮类成分[J]. 华西药学杂志, 2023, 38(5): 548-551.
[51] 王红娟, 胡雯, 雷子贤, 等. 异鼠李素抑制H2O2诱导的黑素细胞ROS水平升高和细胞活性降低[J]. 中国组织化学与细胞化学杂志, 2021, 30(3): 240-245.
[52] Yang, J.H., Shin, B.Y., Han, J.Y., Kim, M.G., Wi, J.E., Kim, Y.W., et al. (2014) Isorhamnetin Protects against Oxidative Stress by Activating Nrf2 and Inducing the Expression of Its Target Genes. Toxicology and Applied Pharmacology, 274, 293-301.
https://doi.org/10.1016/j.taap.2013.10.026
[53] 娜依马·马木提, 胡雯, 康晓静. 异鼠李素激活线粒体自噬缓解人表皮黑素细胞氧化损伤的作用[J]. 中国皮肤性病学杂志, 2026, 40(3): 249-258.
[54] Wang, J.Y., Chen, H., Wang, Y.Y., Wang, X.Q., Chen, H.Y., Zhang, M., et al. (2017) Network Pharmacological Mechanisms of Vernonia anthelmintica (L.) in the Treatment of Vitiligo: Isorhamnetin Induction of Melanogenesis via Up-Regulation of Melanin-Biosynthetic Genes. BMC Systems Biology, 11, Article No. 103.
https://doi.org/10.1186/s12918-017-0486-1
[55] Hu, W., Wang, H., Lei, Z., Li, K., Na, Y. and Kang, X. (2025) Isorhamnetin Protects Melanocytes against CD8+ T Cell-Mediated Apoptosis and Reduces Inflammation in Vitiligo-Afflicted Mouse. Biomedicine & Pharmacotherapy, 191, Article 118456.
https://doi.org/10.1016/j.biopha.2025.118456
[56] 广海东, 郑静静. 中药活性成分高良姜素的分析检测研究进展[J]. 精细化工中间体, 2023, 53(6): 10-16.
[57] 王晓晴, 孙允红, 赵方舒, 等. 高良姜素的药理作用及机制研究进展[J]. 中药药理与临床, 2023, 39(8): 115-120.
[58] Wang, D., Chen, J., Pu, L., Yu, L., Xiong, F., Sun, L., et al. (2023) Galangin: A Food‐Derived Flavonoid with Therapeutic Potential against a Wide Spectrum of Diseases. Phytotherapy Research, 37, 5700-5723.
https://doi.org/10.1002/ptr.8013
[59] 林好, 冯娇, 黄庆谱, 等. 高良姜素对DNA氧化损伤的保护作用及其机制研究[J]. 中国食品添加剂, 2021, 32(5): 1-7.
[60] 沈灵芝, 李莉, 杨舟鑫, 等. 高良姜素通过调控NLRP3炎性小体抑制巨噬细胞焦亡[J]. 中国中西医结合急救杂志, 2024, 31(1): 28-33.
[61] 魏文婧, 徐登球, 阿卜杜热伊木·阿力木江, 等. 高良姜素调节皮肤免疫稳态抗黑色素丢失的作用机制研究[J]. 中药药理与临床, 2026, 42(1): 61-67.

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