基于“痰淤”理论探讨铁死亡和细胞焦亡在慢性心力衰竭中的作用
A Discussion on the Roles of Ferroptosis and Pyroptosis in Chronic Heart Failure Based on the “Phlegm-Stasis” Theory
DOI: 10.12677/tcm.2026.1510587, PDF,   
作者: 刘 烊, 聂 娜：黑龙江中医药大学研究生院，黑龙江 哈尔滨；孙 静*：黑龙江中医药大学附属第一医院心血管科，黑龙江 哈尔滨
关键词: 慢性心力衰竭；铁死亡；细胞焦亡；痰淤理论；改善心功能；Chronic Heart Failure； Ferroptosis； Pyroptosis； Phlegm-Stasis Theory； Improvement in Cardiac Function
摘要: 慢性心力衰竭是心室收缩或舒张功能发生障碍所致，以心功能受损为主要表现，由多种心脏疾患引发的一系列临床症候群，病理机制涉及多种细胞模式的死亡。铁死亡和细胞焦亡作为新型程序的死亡方式近年来被证实与心衰的发生发展有着密切的相关。铁死亡和细胞焦亡通过氧化损伤和炎症的协同作用，可加剧慢性心力衰竭的进程。本文从“痰瘀交互，痰淤同治”之理论，论述慢性心力衰竭的发生发展及其治疗，靶向这两种死亡途径的联合干预可能成为改善心功能及其预后的重要策略，进一步深入探究中医药治疗慢性心力衰竭的内在机制，旨在为中西医结合治疗慢性心力衰竭提供更为详实、可靠的参考依据。
Abstract: Chronic heart failure is a series of clinical syndromes caused by impaired ventricular systolic or diastolic function, primarily manifested by cardiac dysfunction, and triggered by various cardiac diseases. Its pathological mechanisms involve multiple forms of cell death. In recent years, ferroptosis and pyroptosis—as novel forms of programmed cell death—have been shown to be closely associated with the onset and progression of heart failure. Through the synergistic effects of oxidative damage and inflammation, ferroptosis and pyroptosis can exacerbate the progression of chronic heart failure. Based on the theoretical framework of “the interaction between phlegm and blood stasis, and the concurrent treatment of both,” this paper discusses the pathogenesis and progression of chronic heart failure as well as its treatment. Combined interventions targeting these two pathways of cell death may serve as a key strategy for improving cardiac function and prognosis. By further exploring the underlying mechanisms of traditional Chinese medicine (TCM) in treating chronic heart failure, this study aims to provide a more detailed and reliable reference for the integrated treatment of chronic heart failure using both Chinese and Western medicine.
文章引用：刘烊, 聂娜, 孙静. 基于“痰淤”理论探讨铁死亡和细胞焦亡在慢性心力衰竭中的作用[J]. 中医学, 2026, 15(10): 535-544. https://doi.org/10.12677/tcm.2026.1510587

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