基于“阳化气，阴成形”理论探讨氧化应激与子宫内膜异位症的相关性

Exploring the Association between Oxidative Stress and Endometriosis Based on the Theory of “Yang Transforms Qi, Yin Forms Form”

摘要: 子宫内膜异位症(Endometriosis, EMs)是指子宫内膜组织异位生长在子宫腔外，引起盆腔病变等临床症状，影响着全球大约10%的育龄妇女。EMs不仅是雌激素依赖性内分泌疾病，还是全身性炎症疾病，其引起的疼痛与不孕严重影响着EMs患者的生活质量。氧化应激是近年来新兴研究热点，其在EMs中发病机制、诊断以及生物标志物受到妇科学领域广泛关注。氧化应激促进EMs发生发展，开发基于氧化应激的治疗方法对于能否改善EMs患者的症状，缩小病灶大小，改善生活质量，是EMs的研究新方向。“阳化气，阴成形”理论源于《素问·阴阳应象大论》，阐释了阴阳消长转化与万事万物生化之间的关系。女子疾病的发生与“阳化气，阴成形”功能密切相关，故中医治疗EMs需调和阴阳。本文旨在从中医的“阳化气，阴成形”理论角度出发，对氧化应激与子宫内膜异位症之间的关系深入解析。

Abstract: Endometriosis (EMs) refers to the ectopic growth of endometrial tissue outside the uterine cavity, causing clinical symptoms such as pelvic lesions and affecting approximately 10% of women of reproductive age worldwide. EMs is not only an estrogen-dependent endocrine disorder but also a systemic inflammatory disease, with associated pain and infertility significantly impairing patients’ quality of life. Oxidative stress has recently emerged as a key research focus, attracting extensive attention in gynecology regarding its role in the pathogenesis, diagnosis, and biomarkers of EMs. Oxidative stress promotes the development and progression of EMs, and developing therapies based on oxidative stress regulation may offer new directions for improving symptoms, reducing lesion size, and enhancing quality of life in EMs patients. The theory of “Yang transforms qi, Yin forms form” originates from the Suwen·Yin-Yang Ying Xiang Da Lun (The Yellow Emperor’s Inner Canon), elucidating the relationship between the dynamic transformation of Yin and Yang and the generation and change of all things. The occurrence of female diseases is closely related to the functions described by “Yang transforms qi, Yin forms form”; therefore, traditional Chinese medicine (TCM) treatment of EMs emphasizes the harmonization of Yin and Yang. This article aims to explore the relationship between oxidative stress and endometriosis from the perspective of the TCM theory “Yang transforms qi, Yin forms form.”