中药热奄包联合昂丹司琼口溶膜对无痛胃镜后恶心呕吐的短期干预效果研究

Short-Term Effects of a Heated Chinese Herbal Compress Combined with Ondansetron Oral Soluble Film on Nausea and Vomiting after Sedated Gastroscopy

摘要: 目的：评价中药热奄包联合昂丹司琼口溶膜对无痛胃镜后恶心呕吐的短期改善效果。方法：采用随机对照设计，将90例无痛胃镜检查后出现恶心、呕吐的患者分为联合干预组、昂丹司琼口溶膜组和中药热奄包组，每组30例。联合干预组接受中药热奄包腹部热敷和昂丹司琼口溶膜含服，另两组分别接受单一干预。比较干预前及干预后1 h的呕吐次数评分和恶心、呕吐视觉模拟评分(VAS)。结果：三组干预前两项评分差异均无统计学意义(P > 0.05)。干预后，三组两项评分均较干预前下降(P < 0.05)；联合干预组两项评分低于两个单一干预组(P < 0.05)。三组干预后VAS评分依次为3.0 ± 0.63、3.6 ± 0.66和5.5 ± 0.50分。现有资料不足以评价组间安全性差异。结论：联合干预组在1 h观察期内显示较低的症状评分，提示该方案可能具有短期附加获益。鉴于样本量、观察时长、方法学和安全性资料的限制，该发现仍需进一步验证。

Abstract: Objective: To evaluate the short-term effects of a heated Chinese herbal compress combined with ondansetron oral soluble film on nausea and vomiting after sedated gastroscopy. Methods: Ninety patients who developed nausea and vomiting after sedated gastroscopy were randomly assigned to a combination group, an ondansetron oral soluble film group, or a heated Chinese herbal compress group, with 30 patients in each group. The combination group received abdominal application of a heated Chinese herbal compress and ondansetron oral soluble film; the other groups received the corresponding single intervention. Vomiting frequency scores and visual analogue scale (VAS) scores for nausea and vomiting were compared before intervention and 1 h afterwards. Results: Baseline scores did not differ significantly among the three groups (P > 0.05). Both scores decreased in all groups after intervention (P < 0.05), and post-intervention scores were lower in the combination group than in either single-intervention group (P < 0.05). Post-intervention VAS scores were 3.0 ± 0.63, 3.6 ± 0.66, and 5.5 ± 0.50, respectively. The available data were insufficient to assess between-group differences in safety. Conclusion: The combination group had lower symptom scores during the 1-h observation period, suggesting a possible short-term additional benefit. Given the limitations in sample size, observation duration, methodology, and safety data, these findings require further validation.