|
[1]
|
Abdulkareem, A.A., Al-Taweel, F.B., Al-Sharqi, A.J.B., Gul, S.S., Sha, A. and Chapple, I.L.C. (2023) Current Concepts in the Pathogenesis of Periodontitis: From Symbiosis to Dysbiosis. Journal of Oral Microbiology, 15, Article 2197779.
https://doi.org/10.1080/20002297.2023.2197779
|
|
[2]
|
Kwon, T., Lamster, I.B. and Levin, L. (2021) Current Concepts in the Management of Periodontitis. International Dental Journal, 71, 462-476.
https://doi.org/10.1111/idj.12630
|
|
[3]
|
Sirisereephap, K., Maekawa, T., Tamura, H., Hiyoshi, T., Domon, H., Isono, T., et al. (2022) Osteoimmunology in Periodontitis: Local Proteins and Compounds to Alleviate Periodontitis. International Journal of Molecular Sciences, 23, Article 5540.
https://doi.org/10.3390/ijms23105540
|
|
[4]
|
Chen, S., Gao, X. and Song, J. (2023) Oxidative Stress-Related Biomarkers in Chronic Periodontitis Patients with or without Type 2 Diabetes: A Systematic Review and Meta-Analysis. Journal of Periodontal Research, 58, 780-790.
https://doi.org/10.1111/jre.13136
|
|
[5]
|
Boström, P., Wu, J., Jedrychowski, M.P., Korde, A., Ye, L., Lo, J.C., et al. (2012) A PGC1-α-Dependent Myokine That Drives Brown-Fat-Like Development of White Fat and Thermogenesis. Nature, 481, 463-468.
https://doi.org/10.1038/nature10777
|
|
[6]
|
Kim, H., Wrann, C.D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., et al. (2018) Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Cell, 175, 1756-1768.e17.
https://doi.org/10.1016/j.cell.2018.10.025
|
|
[7]
|
Pullisaar, H., Colaianni, G., Lian, A., Vandevska-Radunovic, V., Grano, M. and Reseland, J.E. (2020) Irisin Promotes Growth, Migration and Matrix Formation in Human Periodontal Ligament Cells. Archives of Oral Biology, 111, Article 104635.
https://doi.org/10.1016/j.archoralbio.2019.104635
|
|
[8]
|
Huang, X., Xiao, J., Wang, X. and Cao, Z. (2022) Irisin Attenuates P. Gingivalis-Suppressed Osteogenic/Cementogenic Differentiation of Periodontal Ligament Cells via P38 Signaling Pathway. Biochemical and Biophysical Research Communications, 618, 100-106.
https://doi.org/10.1016/j.bbrc.2022.06.001
|
|
[9]
|
Li, G., Qin, H., Zhou, M., Zhang, T., Zhang, Y., Ding, H., et al. (2023) Knockdown of SIRT3 Perturbs Protective Effects of Irisin against Bone Loss in Diabetes and Periodontitis. Free Radical Biology and Medicine, 200, 11-25.
https://doi.org/10.1016/j.freeradbiomed.2023.02.023.
|
|
[10]
|
Hu, W., Lu, Y., Duan, Y., Yang, Y., Wang, M., Guo, J., et al. (2024) Regulation of Immune Inflammation and Promotion of Periodontal Bone Regeneration by Irisin-Loaded Bioactive Glass Nanoparticles. Langmuir, 40, 3440-3452.
https://doi.org/10.1021/acs.langmuir.3c02894
|
|
[11]
|
Maak, S., Norheim, F., Drevon, C.A. and Erickson, H.P. (2021) Progress and Challenges in the Biology of FNDC5 and Irisin. Endocrine Reviews, 42, 436-456.
https://doi.org/10.1210/endrev/bnab003
|
|
[12]
|
Paoletti, I. and Coccurello, R. (2024) Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology. International Journal of Molecular Sciences, 25, Article 13480.
https://doi.org/10.3390/ijms252413480
|
|
[13]
|
Liu, S., Cui, F., Ning, K., Wang, Z., Fu, P., Wang, D., et al. (2022) Role of Irisin in Physiology and Pathology. Frontiers in Endocrinology, 13, Article 962968.
https://doi.org/10.3389/fendo.2022.962968
|
|
[14]
|
Cosio, P.L., Pelaez, M., Cadefau, J.A. and Farran-Codina, A. (2023) Systematic Review and Meta-Analysis of Circulating Irisin Levels Following Endurance Training: Results of Continuous and Interval Training. Biological Research for Nursing, 25, 367-381.
https://doi.org/10.1177/10998004221142580
|
|
[15]
|
Torabi, A., Reisi, J., Kargarfard, M. and Mansourian, M. (2024) Differences in the Impact of Various Types of Exercise on Irisin Levels: A Systematic Review and Meta-Analysis. International Journal of Preventive Medicine, 15, 1-11.
https://doi.org/10.4103/ijpvm.ijpvm_76_23
|
|
[16]
|
Hatakeyama, J., Inoue, S., Jiang, H., Yokoi, R. and Moriyama, H. (2025) Exercise-Induced Interactions between Skeletal Muscle and Bone via Myokines and Osteokine in Mice: Role of FNDC5/Irisin, IGF-1, and Osteocalcin. Bone, 190, Article 117314.
https://doi.org/10.1016/j.bone.2024.117314
|
|
[17]
|
Mu, A., Wales, T.E., Zhou, H., et al. (2023) Irisin Acts through Its Integrin Receptor in a Two-Step Process Involving Extracellular Hsp90α. Molecular Cell, 83, 1903-1920.e12.
https://doi.org/10.1016/j.molcel.2023.05.008
|
|
[18]
|
Bai, Z., Chen, Z., Sun, T., Ma, C. and Meng, A. (2025) Potential Role of Integrin αV as Irisin Receptor and Advances in Research. Peptides, 193, Article 171439.
https://doi.org/10.1016/j.peptides.2025.171439
|
|
[19]
|
Hu, X., Wang, Z., Wang, W., Cui, P., Kong, C., Chen, X., et al. (2024) Irisin as an Agent for Protecting against Osteoporosis: A Review of the Current Mechanisms and Pathways. Journal of Advanced Research, 62, 175-186.
https://doi.org/10.1016/j.jare.2023.09.001
|
|
[20]
|
Zhao, R., Chen, Y., Wang, D., Zhang, C., Song, H. and Ni, G. (2023) Role of Irisin in Bone Diseases. Frontiers in Endocrinology, 14, Article 1212892.
https://doi.org/10.3389/fendo.2023.1212892
|
|
[21]
|
Chen, Y., Wang, H., Yang, Q., Zhao, W., Chen, Y., Ni, Q., et al. (2022) Single-Cell RNA Landscape of the Osteoimmunology Microenvironment in Periodontitis. Theranostics, 12, 1074-1096.
https://doi.org/10.7150/thno.65694
|
|
[22]
|
Hu, K., Shang, Z., Yang, X., Zhang, Y. and Cao, L. (2023) Macrophage Polarization and the Regulation of Bone Immunity in Bone Homeostasis. Journal of Inflammation Research, 16, 3563-3580.
https://doi.org/10.2147/jir.s423819
|
|
[23]
|
贺欣然, 李元, 张武阳, 等. 牙周炎中巨噬细胞极化、焦亡、胞葬的研究进展[J]. 口腔疾病防治, 2024, 32(11): 886-893.
|
|
[24]
|
Zhang, M., Liu, Y., Afzali, H. and Graves, D.T. (2024) An Update on Periodontal Inflammation and Bone Loss. Frontiers in Immunology, 15, Article 1385436.
https://doi.org/10.3389/fimmu.2024.1385436
|
|
[25]
|
刘旭芳, 马雨轩, 牛丽娜. 线粒体功能障碍在牙周炎发生、发展及治疗中作用的研究进展[J]. 口腔疾病防治, 2023, 31(12): 889-895.
|
|
[26]
|
黄珺玲, 王津津, 王勤涛. 牙周炎环境下人牙龈成纤维细胞线粒体稳态的失衡[J]. 口腔疾病防治, 2024, 32(12): 916-924.
|
|
[27]
|
Tang, H., Zhou, Y., Ma, L., Ye, Y., Xiao, Q., Tang, J., et al. (2025) SIRT3 Alleviates Mitochondrial Dysfunction and Senescence in Diabetes-Associated Periodontitis by Deacetylating LRPPRC. Free Radical Biology and Medicine, 227, 407-419.
https://doi.org/10.1016/j.freeradbiomed.2024.11.033
|
|
[28]
|
Li, G., Jian, Z., Wang, H., Xu, L., Zhang, T. and Song, J. (2022) Irisin Promotes Osteogenesis by Modulating Oxidative Stress and Mitophagy through SIRT3 Signaling under Diabetic Conditions. Oxidative Medicine and Cellular Longevity, 2022, Article 3319056.
https://doi.org/10.1155/2022/3319056
|
|
[29]
|
Zhu, X., Li, X., Wang, X., Chen, T., Tao, F., Liu, C., et al. (2020) Irisin Deficiency Disturbs Bone Metabolism. Journal of Cellular Physiology, 236, 664-676.
https://doi.org/10.1002/jcp.29894
|
|
[30]
|
Yang, Y., Pullisaar, H., Landin, M.A., Heyward, C.A., Schröder, M., Geng, T., et al. (2021) FNDC5/Irisin Is Expressed and Regulated Differently in Human Periodontal Ligament Cells, Dental Pulp Stem Cells and Osteoblasts. Archives of Oral Biology, 124, Article 105061.
https://doi.org/10.1016/j.archoralbio.2021.105061
|
|
[31]
|
Yang, Y., Geng, T., Samara, A., Olstad, O.K., He, J., Agger, A.E., et al. (2023) Recombinant Irisin Enhances the Extracellular Matrix Formation, Remodeling Potential, and Differentiation of Human Periodontal Ligament Cells Cultured in 3D. Journal of Periodontal Research, 58, 336-349.
https://doi.org/10.1111/jre.13094
|
|
[32]
|
Yang, Y., Pullisaar, H., Stunes, A.K., Nogueira, L.P., Syversen, U. and Reseland, J.E. (2023) Irisin Reduces Orthodontic Tooth Movement in Rats by Promoting the Osteogenic Potential in the Periodontal Ligament. European Journal of Orthodontics, 45, 842-853.
https://doi.org/10.1093/ejo/cjad021
|
|
[33]
|
Wu, S., Wang, J., Liu, L., Pang, Y., Li, Z. and Mu, H. (2023) Recombinant Irisin Protects against Alveolar Bone Destruction during Orthodontic Tooth Movement. Inflammation, 46, 1106-1117.
https://doi.org/10.1007/s10753-023-01797-3
|
|
[34]
|
Yang, Y., Wang, M., Zhang, G., Lu, X., Liu, S., Chen, Y., et al. (2025) Irisin-Based Nanocomposites for Antioxidant Purpose and the Promotion of Osteogenesis in the Inflammatory Microenvironment. Langmuir, 41, 23036-23049.
https://doi.org/10.1021/acs.langmuir.5c02711
|
|
[35]
|
Chen, Y., Xu, Z., Xue, Y., Liu, S., Zhang, X., Guo, J., et al. (2026) Cascade Therapy of Periodontitis via Sequential Release of Ribosome-Targeting Antimicrobial Peptide and Irisin from a Multifunctional MOF-Based System. Advanced Science, 13, e21553.
https://doi.org/10.1002/advs.202521553
|
|
[36]
|
李伟光, 吴亚菲, 郭淑娟. 无机纳米粒子在牙周病诊疗中的研究进展[J]. 国际口腔医学杂志, 2022, 49(6): 724-730.
|
|
[37]
|
杨梦瑶, 高现灵, 邓淑丽. 静电纺丝纳米纤维在牙周再生中的应用[J]. 国际口腔医学杂志, 2023, 50(1): 10-18.
|
|
[38]
|
Turkmen, E., Uzun, E.V., Bozaba, F., Balci, N. and Toygar, H. (2023) Salivary Irisin Level Is Higher and Related with Interleukin-6 in Generalized Periodontitis. Clinical Oral Investigations, 27, 3001-3008.
https://doi.org/10.1007/s00784-023-04903-9
|
|
[39]
|
Salim, F.S. and Saliem, S.S. (2025) Irisin, a Promising Adipomyokine, Shows Low Levels in Relation to Periodontal Diseases, Unlike Visfatin and IL-6 (Case-Control Study). Frontiers in Oral Health, 6, Article 1614433.
https://doi.org/10.3389/froh.2025.1614433
|
|
[40]
|
Saribas, E., Kandemir, M., Erkan, R.E.C. and Tuncer, M.C. (2025) Evaluation of Irisin and Interleukin-6 Levels in Saliva Samples of Periodontally Healthy and Stage 3 Grade C Periodontitis Individuals. Biology, 14, Article 1188.
https://doi.org/10.3390/biology14091188
|