育龄人群泌尿生殖道支原体感染情况及耐药性分析

Analysis of the Prevalence of Mycoplasma Infections and Their Drug Resistance in the Urogenital Tract among Reproductive Population

摘要: 目的：了解南宁地区育龄人群泌尿生殖道支原体感染状况及其耐药性特点。方法：对2013年4月~2015年3月在本院就诊的2435例患者生殖道分泌物采用支原体培养鉴别计数药敏试剂盒进行解脲脲原体(Uu)和人型支原体(Mh)检测。结果：支原体感染率为44.97%，女性感染率为60.01%高于男性的29.33%，其中Uu、Mh和Uu+Mh感染率分别为33.96%、1.85%和9.16%。3种感染模式均敏感的有交沙霉素、多西环素和美满霉素，均耐药的为环丙沙星；Uu+Mh对12种抗菌药物耐药率高于Uu，Mh对除交沙霉素外的大环内酯类耐药率高于Uu+Mh，而对除左氧氟沙星外的喹诺酮类、四环素类耐药率低于Uu+Mh。喹诺酮类、大环内酯类和四环素类耐药率分别为84.11%、50.95%和29.95%。结论：南宁地区泌尿生殖道支原体感染率较高，女性高于男性，以Uu感染为主；支原体对常用抗生素的耐药性严重。

Abstract: Objective: To investigate the prevalence of Mycoplasma infections and their drug resistance in the urogenital tract among reproductive population. Methods: Mycoplasma Urealytium and Mycop-lasma hominis were cultured in the urogenital tract specimens form 2435 patients from April 2013 to May 2015, and their drug sensitivity were analyzed. Results: The rate of Mycoplasma infection was 44.97%. It is higher in female (60.01%) than in man (29.33%), and they were 33.96%, 1.85% and 9.16% in patient with Uu, Mh and Uu+Mh infection. Mycoplasma was sensitive to josamycin, doxycycline and minocycline, and resistant against ciprofloxacin. The drug resistance of Uu+Mh for 12 kinds of antibiotic is much higher than Uu. Mh is more resistant to Uu for macrolide antibiotics except for josamycin, and it is low for quinolones and tetracyclines, except for levofloxacin. The rate of drug resistance for quinolones, macrolide antibiotics and tetracyclines was 84.11%, 50.95% and 29.95% respectively. Conclusion: The infection rate of Mycoplasmain the urogenital tract is high in Nanning. It is more obvious in female, mainly the infection rate of Uu. The drug resistance of mycoplasma for antibiotics was extensive.