中药短柱肖菝葜根部位化学成分的研究

Chemical Constituents from the Root of Heterosmilax yunnanensis Gagnep

摘要: 短柱肖菝葜根部入药，习称“白土苓”，是抗肿瘤药物复方苦参注射液的味药之一，对其的化学成分和药理活性研究较少。本文主要对中药短柱肖菝葜根部位中的高极性化学成分展开研究，从中共分离和鉴定了12个化合物：大泽明素(1)、苏铁素(2)、3,4,5-三羟基苯甲醛(3)、3,4-二羟基苯甲醛(4)、4-羟基苯甲酸(5)、3,4-二羟基苯甲酸(6)、2,5-二羟基苯甲酸(7)、3,5-二甲氧基-4-羟基苯甲酸(8)、反式桂皮酸(9)、4-乙氧基-苯丙烯酸(10)、4-(二甲氧基甲基)-苯酚(11)和N-3-(3,5-dihydroxy-4,4-dimethyl-1-oxopentyl)- β-Alanine (12)。除化合物1以外，其他化学成分均是首次从该属植物中分离得到，该项研究丰富了短柱肖菝葜的物质基础。

Abstract: The root of Heterosmilax yunnanensis Gagnep. is the main component of anti-cancer drug Com-pound Kushen Injection. The chemical constituents in its high polarity fraction were investigated in this research. Twelve compounds were isolated from 30% ethanol macroporous resin fractions of the root of Heterosmilax yunnanensis Gagnep. and identified as: macrozamin (1), cycasin (2), 3,4,5-trihydroxy benzaldehyde (3), 3,4-dihydroxy benzaldehyde (4), 4-hydroxy benzoic acid (5), 3,4-dihydroxy benzoic acid (6), 2,5-dihydroxy-benzoic acid (7), 3,5-dimethoxyl -4-hydroxy benzoic acid (8), trans-Cinnamic acid (9), 4-ethyoxyl-Cinnamic acid (10), 4-(dimeth-oxymethyl)-phenol (11), N-3-(3,5-dihydroxy-4,4-dimethyl-1-oxopentyl)-β-Alanine (12) respectively. All compounds except 1 are firstly isolated from the Heterosmilax yunnanensis Gagnep. These compounds can support abundant material basis for the further research of Heterosmilax yunnanensis Gagnep.