微纳结构CaTiO3/TiO2复合材料的制备及生物学性能
Preparation and Biological Evaluation of Micro/Nanostructured CaTiO3/TiO2 Composites
DOI: 10.12677/MS.2017.72026, PDF,    国家自然科学基金支持
作者: 尹 露, 周 杰, 高丽丽, 翁 杰, 冯 波：西南交通大学材料先进技术教育部重点实验室，材料科学与工程学院，四川 成都
关键词: 钛；微纳CaTiO3/TiO2；水热反应；蛋白吸附；成骨细胞；Titanium； Micro/-Nanostructured CaTiO3/TiO2； Hydrothermal Reaction； Protein Adsorption； Osteoblasts
摘要: 植入物表面的形貌和成分是影响细胞行为和组织再生的重要因素。采用钙盐和酸的混合液使钛表面形成微孔，再经阳极氧化产生TiO2纳米管层，然后置于Ca(OH)2溶液中水热处理1~4 h，获得具有不同钙含量的钛基微纳结构CaTiO3/TiO2复合材料。通过蛋白吸附和体外成骨细胞培养评价其生物学性能。相对于1 h和4 h，水热反应时间为2 h的CaTiO3/TiO2复合材料具有最强的吸附蛋白能力、成骨细胞显示出最好的增殖行为和最高的成骨活性。具有适当钙含量的三维微纳结构钛CaTiO3/TiO2复合材在硬组织修复替换领域有着良好的应用前景。
Abstract: Surface topography and chemical compositions play important roles in cell behaviors and tissue regeneration. In this work, titanium plates were etched with a mixture of calcium salt and acid to create a micro-porous surface, and then anodized to generate a TiO2 nanotube layer, finally hy-drothermally treated in Ca(OH)2 solution for 1 - 4 h to obtain titanium-based micro/- nanostructured CaTiO3/TiO2 composites with different Ca2+ contents. Biological properties of the composites were evaluated by protein adsorption and osteoblast culture in vitro. The composites by hydrothermal treatment for 2 h show optimal properties to promote protein adsorption, osteoblast proliferation and differentiation. The micro/-nanostructured CaTiO3/TiO2 composite with a suitable content of calcium is a promising candidate of biomaterial for bone replacement.
文章引用：尹露, 周杰, 高丽丽, 翁杰, 冯波. 微纳结构CaTiO3/TiO2复合材料的制备及生物学性能[J]. 材料科学, 2017, 7(2): 204-211. https://doi.org/10.12677/MS.2017.72026

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