壳聚糖抗菌剂研究进展
Research Progress on Chitosan Antimicrobial
DOI: 10.12677/BP.2017.74006, PDF,   
作者: 吴茂涛*：青岛双瑞海洋环境工程股份有限公司，山东 青岛
关键词: 壳聚糖；抗菌剂；机理；展望；Chitosan； Antimicrobial； Mechanism； Prospect
摘要: 壳聚糖是一种天然的高分子，随着研究的深入发展，应用范围越来越广泛。本文概述了壳聚糖在抗菌剂领域的研究应用情况，归纳总结了其抗菌机理及其影响因素，同时展望了壳聚糖抗菌剂的发展前景。
Abstract: Chitosan is a nature macromolecule. With the investigation, its applications are broad. The article summarizes the research and application of chitosan as an antimicrobial, the mechanism and the infective factors, and the development foreground of the chitosan antimicrobial is prospected.
文章引用：吴茂涛. 壳聚糖抗菌剂研究进展[J]. 生物过程, 2017, 7(4): 41-48. https://doi.org/10.12677/BP.2017.74006

参考文献

[1] Sandford, P.A. (1988) Chitosan: Commercial Uses and Potential Applications, in Chitin and Chitosan. Sources, Chemistry, Biochemistry Physical Properties and Applications, Elsevier Applied Science, London.
[2] 汪玉庭, 刘玉红, 张淑琴. 甲壳素/壳聚糖的化学改性及其衍生物应用的研究进展[J]. 功能高分子学报, 2002, 15(1): 107.
[3] Rinaudo, M. and Domard, A. (1988) Solution Properties of Chitosan, in Chitin and Chitosan. Elsevier Applied Science Publishers, London.
[4] Do-mard, A. and Rinaudo, M. (1983) Preparation and Characterization of Fully Deacetylated Chitosan. International Journal of Biological Macromolecules, 5, 49-52. [Google Scholar] [CrossRef] 
[5] 季君晖. 国外塑料用抗菌剂及抗菌塑料[J]. 国外塑料, 2004, 22(3): 38-42.
[6] 孙洪, 夏英, 陈莉. 国内外抗菌剂的研究现状及发展趋势[J]. 塑料工业. 2009, 34(9): 1-4.
[7] 刘碧源, 高仕英. 中国生化药物杂志[J]. 2004, 24(5): 268-270.
[8] 夏金兰, 王春, 刘新星. 抗菌剂及其抗菌机理[J]. 中南大学学报, 2004, 35(1): 36.
[9] 江霞, 徐铭, 张丽. 壳聚糖衍生物在饲料工业中的应用前景[J]. 上海畜牧兽医通讯, 2008(1): 69-71.
[10] Young, D.H. Knole, H.E. and Kauss, H.E. (1983) Release of Calcium from Suspension-Cultured Glycine Max Cells by Chitosan. Plant Physiology, 3, 698-702.
[11] Hadwieger, L.A., Kendra, D.F. and Fristensky, B.W. (1985) Chitin in Nature and Technology. Plenum Press, New York, 120.
[12] 叶磊, 何立千, 高天洲, 等. 壳聚糖的抑菌作用及其稳定性研究[J]. 北京联合大学学报: 自然科学版, 2004, 18(1): 79-82.
[13] 宋献周, 沈月新. 不同平均分子量的壳聚糖的抑菌作用[J]. 上海水产大学学报, 2000, 9(2): 138-141.
[14] 陈凌云, 杜予民, 刘义. 羧甲基壳聚糖的结构与抗菌性能研究[J]. 武汉大学学报(自然科学版), 2000, 46(2): 191-194.
[15] 郑连英, 朱江峰, 孙昆山. 壳聚糖的抗菌性能研究[J]. 材料科学与工程, 2000, 18(2): 22-24.
[16] Jeon, Y.J., Park, P.J. and Kim, S.K. (2001) Antimi-erobial Effect of Chitooligosac-Chardes Produced by Bioreactor. Carbohydrate Polymers, 44, 71-76. [Google Scholar] [CrossRef] 
[17] Helander, I.M., Nurmiaho-Lassila, E.L., Ahvenainen, R., et al. (2001) Chitosan Disrupts the Barrier Properties of the Outer Membrane of Gram-Negative Bacteria. International Journal of Microbi-ology, 71, 235-244. [Google Scholar] [CrossRef] 
[18] Issam, S.T., Adele, M.G., Adele, C.P., et al. (2005) Chitosan Polymer as Bioactive Coating and Film against Aspergillus niger Contamination. Journal of Food Science, 70, 100-104. [Google Scholar] [CrossRef] 
[19] Coma, V., Deschamps, A. and MartialGros, A. (2003) Bioac-tive Packaging Materials from Edible Chitosan Polymer-Antimicrobial Activity Assessment on Dairy-Related Contaminants. Journal of Food Science, 68, 2788-2792. [Google Scholar] [CrossRef] 
[20] Ohtakara, A., Izume, M. and Mitsutomi, M. (1998) Action of Microbial Chitinase on Chitosan with Different Degree of Deacetylation. Agricultural and Biological Chemistry, 52, 3181-3182.
[21] 付强. 甲壳素/壳聚糖及其衍生物抗菌性的研究[D]: [硕士学位论文]. 天津: 天津大学, 1998.
[22] 李治, 刘晓非, 管云林. O-羧甲基壳聚糖抗菌性的研究[J]. 日用化学工业, 2006, 6(3): 10-11.
[23] Kim, C.H., Choi, J.W., Heung, et al. (1997) Synthesis of Chitosan Derivatives with Quaternary Ammonium Salt and Their Antibacterial Activity. Polymer Bulletin, 38, 387. [Google Scholar] [CrossRef] 
[24] Song, J.W., Ghim, H.D., Choi, J.H., et al. (2001) Preparation of Antimicrobial Sodium Alginate with Chito-Oligosaccharide Side Chains. Journal of Applied Polymer Science, 39, 1810-1816. [Google Scholar] [CrossRef] 
[25] Sudharshan, N.R., Hoover, D.G. and Knorr, D. (1992) Antibacterial Action of Chitosan. Food Biotechnology, No. 6, 257-272. [Google Scholar] [CrossRef] 
[26] Tsai, G.J. and Su, W.H. (1999) Antibacterial Activity of Shrimp Chitosan against Eacherichia coli. Journal of Food Protection, 62, 239-243. [Google Scholar] [CrossRef] 
[27] Allan, C. and Adniger, L.A. (1979) The Fungicidal Effect of Chitosan on Fungi of Varying Cell Wall Composition. Experimental Mycology, 3, 285-287. [Google Scholar] [CrossRef] 
[28] 张宓, 谭天伟, 袁会珠. 壳聚糖杀虫与壳低聚糖抑菌活性研究[J]. 北京化工大学学报, 2003, 30(4): 13-16.
[29] 胡健, 姜涌明, 殷士学. 壳寡糖抑制植物病原菌生长的研究[J]. 扬州大学学报, 2000, 3(2): 42-44.
[30] Wei, X.K. and Lei, C.L. (2004) Studies on the Antimicrobial Activity of Chitooligosac-charides from Housefly Larvae, Musca domestica vicina Macquart (Diptera: Muscidae). Agricultural Sciences in China, 3, 299-304.
[31] 刘碧源, 高仕瑛, 李邦良, 等. 壳寡糖抗菌活性的实验研究[J]. 中国生化药物杂志, 2003, 24(2): 73-75.
[32] Ludovic, R., Philippe, L., Elisabeth, P., et al. (2004) Layer by Layer Buildup of Polysaccharide Films: Physical Chemistry and Cellular Adhesion Aspects. Langmuir, 20, 448-458. [Google Scholar] [CrossRef] [PubMed]
[33] Hu, S.-G., Jou, C.-H. and Yang, M.-C. (2003) Antibacterial and Biodegradable Properties of Polyhydroxyalkanoates Grafted with Chi-tosan and Chitooligosaccharides via Ozone Treatment. Journal of Applied Polymer Science, 88, 2797-2803. [Google Scholar] [CrossRef] 
[34] Ming, Y.J., Yu, S.W., Lang, L.T., et al. (2004) Evaluation of Chitosan/PVA Blended Hydrogel Membranes. Journal of Membrane Science, 236, 39-51.
[35] Wu, Y.-B., Yu, S.-H., Mi, F.-L., et al. (2004) Preparation and Characterization on Mechanical and Antibacterial Properties of Chitosan/Cellulose Blends. Carbohydrate Polymers, 57, 435-440. [Google Scholar] [CrossRef] 
[36] Kim, C.H., Kim, S.-Y., et al. (1997) Synthesis and Antibacterial Ac-tivity of Water-Soluble Chitin Derivatives. Polymers for Advanced Technologies, 8, 319-325. [Google Scholar] [CrossRef] 
[37] Nam, C.-W., Kim, Y.-H. and Ko, S.-W. (1999) Modification of Polyacrylonitrile (PAN) Fiber by Blending with N-(2-hydroxy)propyl-3-trimethyl-ammonium Chitosan Chloride. Journal of Applied Polymer Science, 74, 2258-2265.
[38] Seong, H.-S., Whang, H.S. and Ko, S.-W. (2000) Synthesis of a Quanternary Ammonium Derivative of Chitooligosaccharide as Antimicrobial Agent for Cellulosic Fibers. Journal of Applied Polymer Science, 76, 2009-2015.
[39] 张艳艳, 马启敏, 江志华. 壳聚糖季铵盐的合成及性质研究[J]. 中国海洋大学学报, 2005, 35(3): 459-462.
[40] 吴迪, 蔡伟民. 壳聚糖季铵盐的抑菌机理研究[J]. 哈尔滨工业大学学报, 2005, 37(7): 1014-1018.
[41] 李世迁, 姚评佳, 魏远安, 等. 羧甲基壳聚糖季铵盐的制备及其抑菌性能研究[J]. 化学与生物工程, 2006, 11(23): 22-24.
[42] 徐旭凡. 多功能聚氨酯涂层织物的制备及性能[J]. 纺织学报, 2006, 3(23): 71-73.
[43] 周箭, 杨辉. 组装型复合抗菌聚氨酯的抗菌性能[J]. 稀有金属材料与工程, 2004(12): 262-264.
[44] 朱亚伟, 任学宏, 胡韵. 纺织品抗菌后整理加工现状[J]. 印染助剂, 2005, 21(1): 10-14.
[45] 曾涵, 赵淑贤, 王永疆, 等. 3,4-二羟基噻吩交联壳聚糖的合成及其对白桃的抑菌保鲜性能[J]. 应用化学, 2010, 27(11): 1265-1271.