CypA在冠状动脉粥样硬化性心脏病中作用的研究进展
Research Progress on the Role of CypA in Coronary Heart Disease
DOI: 10.12677/ACM.2017.75053, PDF,   
作者: 朱志强：承德医学院，河北 承德；郭靖涛, 周 江, 张金艳：承德医学院第二附属医院，河北 承德
关键词: 亲环素A；动脉粥样硬化；冠状动脉粥样硬化性心脏病；胆固醇代谢；Cyclophilin A； Atherosclerosis； Coronary Heart Disease； Cholesterol Metabolism
摘要: 亲环素A (Cyclophilin A, CypA)属于亲环素家族最重要成员之一，是一种广泛分布的、丰富的、高度保守的蛋白质。它具有肽基脯氨酰顺反异构酶(PPIase)活性和分子伴侣效应。在细胞内，它具有蛋白折叠、运输、细胞内信号传导和调节其他蛋白转录活性等作用。在细胞外，亲环素A (CypA)作为一种氧化应激诱导分泌因子，可刺激血管平滑肌细胞迁移、增殖，增加内皮细胞黏附、分子表达和介导炎性反应，并参与免疫抑制和胆固醇的代谢，促进动脉粥样硬化(Atherosclerosis, AS)的发生发展，与冠状动脉粥样性心脏病(Coronary heart disease, CHD)的形成关系密切。
Abstract: Cyclophilin A (CypA), one of the most important members of the cyclophilin family, is a widely distributed, abundant and highly conserved protein. It has peptidyl-prolyl cis-trans isomerase (PPIase) activity and molecular chaperone effect. It has many intracellular functions, like protein folding and transportation, intracellular signal transduction and regulation of other protein tran-scription activities and so on. Outside cells, CypA, as an oxidative stress-induced secretion factor, can stimulate the migration and proliferation of vascular smooth muscle cells. It can also increase the adhesion of endothelial cells, molecular expression, and mediate inflammatory responses, and participate in immunosuppression and the metabolism of cholesterol. Besides, CypA can promote the occurrence and development of atherosclerosis and has close relations with the formation of coronary atherosclerotic heart disease.
文章引用：朱志强, 郭靖涛, 周江, 张金艳. CypA在冠状动脉粥样硬化性心脏病中作用的研究进展[J]. 临床医学进展, 2017, 7(5): 314-320. https://doi.org/10.12677/ACM.2017.75053

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