一氧化氮与阿兹海默氏症的治疗
Roles of Nitric Oxide in Treatment of Alzheimer’s Disease
DOI: 10.12677/AR.2017.44008, PDF,    国家自然科学基金支持
作者: 王家卉, 邵亚兰, 石 静, 江耀飞, 谢小明, 方 婷, 杨树龙*：南昌大学基础医学院 生理教研室，江西 南昌；万 函：南昌市卫生学校 外科教研室，江西 南昌；洪芬芳：南昌大学 医学实验教学中心 寄生虫实验室，江西 南昌
关键词: 一氧化氮；阿兹海默氏症；治疗；Nitric Oxide； Alzheimer’s Disease； Treatment
摘要: 阿尔茨海默症(Alzheimer’s Disease, AD)是一种原发性神经退行性病变，常伴有认知障碍和神经功能障碍。一氧化氮(nitric oxide, NO)是一种重要的传递神经信息的信号分子，对Aβ的生成有重要影响，同时，通过降低神经炎症和氧化氮化及NF-κB通路抑制诱导性一氧化氮合成酶(inducible nitric oxide synthetase, iNOS)，从而治疗AD。本文就NO影响AD的发病和治疗的相关性最新研究进行综述。
Abstract: Alzheimer’s disease (AD) is a primary neurodegenerative disorder with cognitive impairment and autonomic nervous system dysfunction. Nitric oxide (NO) is a major signaling molecule in neurons which influences the formation of Aβ. In addition, NO reduces neurogenic inflammation, oxidation and nitridation and NF-κB passway to restrain inducible nitric oxide synthetase (iNOS). This paper reviewed NO effects on the development and therapy of AD.
文章引用：王家卉, 邵亚兰, 石静, 江耀飞, 谢小明, 方婷, 万函, 洪芬芳, 杨树龙. 一氧化氮与阿兹海默氏症的治疗[J]. 老龄化研究, 2017, 4(4): 55-61. https://doi.org/10.12677/AR.2017.44008

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