FFR、CFR对急性心肌梗死急诊冠脉介入术后患者预后的相关性研究

The Study of FFR and CFR for the Prognosis of Primary Coronary Intervention in Patients with Acute Myocardial Infarction

摘要: 目的：探讨冠脉血流的功能性指标血流储备分数(FFR)、冠脉血流储备(CFR)对AMI急诊PCI术后患者的预后的影响。方法：选择2011年6月至2014年6月，在上海市奉贤区中心医院心内科就诊的急性心肌梗死患者56例，根据FFR及CFR界限值分4组：A组(15例)：FFR ≥ 0.75，CRF ≥ 1.4；B组(11例)：FFR ≥ 0.75，CFR < 1.4；C组(13例)：FFR < 0.75，CRF ≥ 1.4；D组(17例)：FFR < 0.75，CFR < 1.4。结果：经过平均6个月临床随访后，D组患者总的MACE事件发生率明显高于A，B，C组(P < 0.05)，且主要体现在总死亡率的明显增高(17.6% VS. 0%, P < 0.01)。结论：AMI患者FFR，CFR均低于异常界限值时，MACE事件发生率高，应引起临床医师的高度关注。

Abstract: Objective: To explore the effect of FFR and CFR on the prognosis of Primary Coronary Intervention (PCI) in patients with Acute Myocardial Infarction (AMI) emergency PCI. Methods: 56 cases with AMI were selected, according to the FFR and CFR boundary values of 4 groups: group A (15 cases): FFR ≥ 0.75, CRF ≥ 1.4; Group B (11 cases): FFR ≥ 0.75, CFR < 1.4; Group C (13 cases): FFR < 0.75, CRF ≥ 1.4; Group D (17 cases): FFR < 0.75, CFR < 1.4. Results: After an average of 6 months of clinical follow-up, the incidence of MACE in group D patients was significantly higher than that of A, B, and C (P < 0.05), and mainly reflected in a significant increase in total mortality (17.6% VS. 0%, P < 0.01). Conclusion: The incidence of MACE was high when the patients with AMI FFR and CFR were all below the abnormal threshold value, and should be highly concerned by clinicians.