5-氟尿嘧啶/壳聚糖载药微球的制备及性能研究
Preparation and Properties 5-Fluorouracil-Loaded Chitosan Microsphere
DOI: 10.12677/MS.2017.79101, PDF,    科研立项经费支持
作者: 陈雨婷, 程凤梅, 张雷浩, 缪玉霜, 袁海琴, 李 晶：嘉兴学院材料与纺织工程学院，浙江 嘉兴
关键词: 5-氟尿嘧啶；壳聚糖；微球；缓释；5-Fluorouracil； Chitosan； Microspheres； Sustained-Release
摘要: 选择高分子材料壳聚糖为药物载体，戊二醛为交联剂，司班-80和硬脂酸镁为复合乳化剂，液体石蜡和真空泵油为混合油相，采用乳液-化学交联法制备了5-氟尿嘧啶/壳聚糖载药微球。考察了载药微球的微观形貌、尺寸和药物包封率等理化性能，并对微球的释药性能进行了研究评价。结果表明微球表面结构规整、均匀，壳聚糖与5-氟尿嘧啶之间存在着比较强的分子间作用力，粒径在400 nm左右，且分散性比较好，药物包封率可达87.6%。在pH = 7.4和pH = 1.2的缓冲溶液中都有较好的缓释效果，但pH值越低条件下的缓释效果越好。5-氟尿嘧啶与壳聚糖的质量投料比越小，微球的释药速率越快。
Abstract: 5-Fluorouracil/chitosan (5-Fu/Cs) microspheres were prepared in emulsion by using glutaralde-hyde as cross-linking agent, span-80 and magnesium stearate mixture as emulsifier, and paraffin oil-vacuum pump oil mixture as oil phase. The morphology, dimension and drug-encapsulation capabilities of 5-Fu/Cs microspheres were explored. The surface of 5-Fu/Cs microspheres is smooth, and the dimension is regular and uniform (~400 nm); strong interaction between the 5-Fu and Cs has been found. The drug encapsulation efficiency was determined (~87.6%). The microspheres showed excellent sustained-release effect in buffer solutions with pH = 7.4 and pH = 1.2, while higher release rate was found in lower pH solution. In addition, the release was also affected by the feed ratio of 5-Fu to Cs. With decreasing weight fraction of 5-Fu, increasing releasing rate was found.
文章引用：陈雨婷, 程凤梅, 张雷浩, 缪玉霜, 袁海琴, 李晶. 5-氟尿嘧啶/壳聚糖载药微球的制备及性能研究[J]. 材料科学, 2017, 7(9): 776-782. https://doi.org/10.12677/MS.2017.79101

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