咽喉润滑喷雾剂联合用药改善口干燥症的疗效观察

Observation on the Effect of Throat Lubrication Spray Combined with Medication on Oral Dryness

摘要: 目的：观察咽喉润滑喷雾剂联合白芍总苷胶囊和硫酸羟氯喹片治疗原发性干燥综合征口干燥症的临床疗效。方法：根据随机数字表法将干燥综合征口干燥症患者随机分为治疗组和对照组，每组各32例。治疗组予咽喉润滑喷雾剂，喷咽喉部10下(约2 ml)，含10秒钟后缓慢咽下，3次/d；白芍总苷胶囊，0.6 g/次，3次/d；硫酸羟氯喹片，0.2 g/次，1次/d；对照组给予白芍总苷胶囊和硫酸羟氯喹片，用法用量同治疗组。两组疗程均为4周。记录治疗前后两组的口干调查问卷积分，静态唾液流率、方糖试验积分以及血沉(ESR)、C反应蛋白(CRP)、免疫球蛋白(IgG、IgM、IgA)的水平。结果：两组均可改善干燥综合征口干燥症，增加静态唾液流率，降低方糖试验积分以及改善血沉(ESR)、C反应蛋白(CRP)、免疫球蛋白(IgG、IgM、IgA)的水平(P均 < 0.05)，但治疗组在增加静态唾液流率，降低方糖试验积分方面疗效显著(P < 0.01)。结论：咽喉润滑喷雾剂联合白芍总苷胶囊和硫酸羟氯喹片能明显改善患者口干燥症状，降低血沉(ESR)、C反应蛋白(CRP)、免疫球蛋白(IgG、IgM、IgA)水平，并且不良反应发生率低。

Abstract: Objective: To observe the clinical effect of throat lubricating spray combined with total paeoniflorin capsules in the treatment of Sjögren’s Syndrome with dry syndrome. Methods: The patients with dry syndrome were randomly divided into treatment group and control group according to the random number table method. The treatment group to the throat lubricating spray, spray throat 10 (about 2 ml), with 10 seconds after the slow swallow, 3 times/d, paeoniflorin capsules, 0.6 g times, 3 times/d, Hydroxychloroquine sulfate tablet, 0.2 g times, 1 times/d. The control group was given total paeoniflorin capsules, the dosage was the same as the treatment group. Both groups were treated for 4 weeks. To records two groups before and after treatment of xerostomia questionnaire score, salivary flow rate, static test and integration of sugar, ESR, C reactive protein (CRP), immunoglobulin (IgG, IgM, IgA) level. Results: The two groups can improve xerostomia sicca syndrome, increase static salivary flow rate, reducing sugar test and improve the integral erythrocyte sedimentation rate (ESR), C reactive protein (CRP), immunoglobulin (IgG, IgM, IgA) level (P < 0.05), but the treatment group increased static salivary flow rate, reduce the effect of sugar test scores significantly (P < 0.01). Conclusion: The throat spray lubrication combined with Total Glucosides of Paeony Capsules and Hydroxychloroquine sulfate tablet can significantly improve patients with dry mouth symptoms, reduce the erythrocyte sedimentation rate (ESR), C reactive protein (CRP), immunoglobulin (IgG, IgM, IgA) level, and low incidence of adverse reactions.