血府逐瘀汤干预冠脉造影术后对比剂肾病的临床研究

The Clinical Study of Xuefu Zhuyu Decoction in the Intervention of Contrast-Induced Nephropathy after Coronary Angiography

摘要: 目的：观察血府逐瘀汤干预冠状动脉造影术对比剂肾病的临床研究。方法：纳入冠状动脉造影术患者200例，随机分为常规治疗组(n = 100)和血府逐瘀汤干预组(n = 100)，两组患者在冠状动脉造影术前、后常规给予抗血小板、调脂及常规水化治疗，且均不禁食、禁水，血府逐瘀汤干预组在此基础上，于冠状动脉造影术前3天和术后7天加用血府逐瘀汤干预，每天一剂；检测各组患者血清肌酐(Scr)、肾小球滤过率估测值(eGFR)在冠脉造影前后改变。结果：血府逐瘀汤干预组血清肌酐(Scr)、肾小球滤过率估测值(eGFR)的变化明显低于常规治疗组(P < 0.01)。结论：血府逐瘀汤对冠状动脉造影术中的肾脏具有保护作用，明显减少对比剂肾病的发生。

Abstract: Objective: To observe and study Xuefu Zhuyu Decoction in the intervention of contrast-induced nephropathy after coronary angiography. Methods: 100 patients with coronary artery angiogra-phy were randomly divided into conventional treatment group (n = 100) and Xuefu Zhuyu Decoction intervention group (n = 100), intervention group is added with Xuefu Zhuyu Decoction intervention 3 days before and 7 days after the coronary angiography, once a day. Results: The serum creatinine (Scr) and estimated glomerular filtration rate (eGFR) changes of intervention group is significantly lower than the routine treatment group (P < 0.01). Conclusions: Xuefu Zhuyu Decoction have protective effects on the kidney in coronary artery angiography, significantly reduces the happening of the contrast-induced nephropathy.