铜催化苄腈化合物与二级胺合成三级酰胺
Cu-Catalyzed Benzyl Cyanide and Secondary Amines for the Synthesis of Tertiary Amides
DOI: 10.12677/SSC.2018.61002, PDF,    国家自然科学基金支持
作者: 崔晓红, 乔 助, 黄 轩, 杨小琴, 陈秀玲, 孙绍发*：湖北科技学院核技术与化学生物学院/非动力核技术研发中心，湖北 咸宁
关键词: 铜催化；苄腈；二级胺；三级酰胺；Cu-Catalyzed； Benzyl Cyanide； Secondary Amines； Tertiary Amides
摘要: 酰胺是天然产物中普遍存在的功能基团，是蛋白质的重要组成部分。酰胺在许多合成药物、医药和精细化学品的合成中有着广泛的应用。本文报道了一种新颖的铜催化氧化苄腈化合物与二级酰胺合成三级酰胺化合物的方法。在最优反应条件下，含有吸电子取代基或者给电子取代基的苄腈化合物都可以与二级胺反应高产率地合成三级酰胺化合物。
Abstract: Amides are common functional groups that have widely existed in natural products which are the key building blocks of proteins. Amides have wide applications in the synthesis of many synthetic drugs, pharmaceuticals and fine chemicals. Herein, we report a novel copper-catalyzed oxidative benzyl cyanide and secondary amines for the synthesis of tertiary amides. Under the optimal reaction condition, both electron-rich and electron-deficient group substituted 2-phenylacetonitrile with secondary amines could give the amide products in high yields.
文章引用：崔晓红, 乔助, 黄轩, 杨小琴, 陈秀玲, 孙绍发. 铜催化苄腈化合物与二级胺合成三级酰胺[J]. 合成化学研究, 2018, 6(1): 8-14. https://doi.org/10.12677/SSC.2018.61002

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