慢性牙周炎伴冠心病患者龈沟液及血清中瘦素水平的研究

The Levels of Leptin in Serum and Gingival Crevicular Fluid in Chronic Periodontitis with Coronary Heart Disease

摘要: 目的：研究慢性牙周炎伴冠心病患者龈沟液及血清中瘦素的表达水平。方法：检测对照组、试验组(慢性牙周炎组、冠心病组、冠心病伴慢性牙周炎组)血清及龈沟液标本瘦素水平，并对患有牙周炎的病例进行牙周基础治疗后一个月三个月时的血清及龈沟液中瘦素进行检测。结果：试验组血清中瘦素含量高于对照组(P < 0.01)，其中以冠心病伴慢性牙周炎组最高。龈沟液中瘦素水平试验组低于对照组(P < 0.01)。牙周基础治疗后一个月，慢性牙周炎组及冠心病伴慢性牙周炎组血清中瘦素水平降低(P < 0.01)，三个月后慢性牙周炎组血清及龈沟液中瘦素以及慢性牙周炎伴冠心病组血清中瘦素接近对照组水平(P > 0.05)，但其龈沟液中瘦素与对照组还存在显著性差异(P < 0.05)。结论：瘦素在慢性牙周炎及冠心病中起到重要作用，血清及龈沟液中的瘦素变化与牙周基础治疗有关。

Abstract: Objective: To detect the levels of leptin in serum and gingival crevicular fluid (GCF) in chronic pe-riodontitis (CP) with coronary heart disease (CHD). Methods: The leptin levels in serum and in gingival cervicular fluid (GCF) in CP, CHD, CP+CHD and subject of healthy people (SHP) were assayed, and assayed again 1, and 3 months after periodontal therapy in CP and CP+CHD. Results: The levels of leptin in CP, CHD, and CP+CHD were higher than those in SHP (P < 0.01), and the CP+CHD were the highest. The lectin in GCF was reversed (P < 0.01). At 1 month after treatment, the levels of lectin in serum and GCF were significantly reduced (P < 0.01). The levels of lectin in serum and GCF in CP and serum in CP+CHD were changed nearly to those in SHP (P > 0.05). But those in GCF in CP+CHD were different (P < 0.05). Conclusion: Leptin may be involved in the interaction of chronic periodontitis and coronary heart disease. The periodontal therapy can change the level of lectin in serum and GCF.