阿尔兹海默病发病机理概述及治疗策略展望
An Overview of Alzheimer’s Disease Pathogenesis and the Outlook for Its Treatment
摘要: 阿尔兹海默病(Alzheimer’s disease, AD)是最常见的一类的神经退行性疾病,也是最常见的一类痴呆病,高发于老龄群体。AD临床症状包括语言障碍、记忆丢失、易怒、抑郁等认知功能障碍及行为异常;AD病理特征主要包括神经元外β-淀粉样蛋白(β-amyloid, Aβ)沉积形成的老年斑(senile plaques, SPs)和神经元内Tau蛋白过度磷酸化形成的神经原纤维缠结(neurofibrillary tangles, NFTs)、神经元丢失等。尽管AD发病机理至今尚不清楚,但越来越多的证据表明Aβ与AD病理紧密相关,本文综述Aβ诱导的氧化应激、炎症反应及神经元调亡与AD病理的相关性,以期为AD新药研发提供新的思路。
Abstract: Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and its prevalence is closely related to aging, and also the most common cause of dementia. AD is clinically characterized by cognitive deficits and behavioral disorders like language disorders, memory loss, agitation and depression. AD is pathologically characterized by senile plaques (SPs) composed of β-amyloid (Aβ), neurofibrillary tangles (NFTs) caused by hyperphosphorylated Tau proteins, and neuronal loss. AD pathogenesis is not well understood yet, but a body of evidence shows that Aβ plays a critical role in AD pathology. In this paper, we review the role of Aβ-induced oxidative stress, neuroinflammation and neuronal apoptosis in AD pathology, aiming to provide new ideas for the development of new therapeutic drugs against AD.
文章引用:王天佐, 张莹, 薛真真, 朱启顺. 阿尔兹海默病发病机理概述及治疗策略展望[J]. 临床医学进展, 2018, 8(1): 85-92. https://doi.org/10.12677/ACM.2018.81016

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