肾细胞癌扩散峰度成像的可行性及可重复性研究

Diffusion Kurtosis Imaging of Renal Cell Carcinoma: Study of Its Feasibility and Reproducibility

摘要: 背景：探讨肾细胞癌磁共振扩散峰度成像(DKI)的可行性及测量参数的可重复性，为临床治疗及判断预后提供依据。方法：搜集48例经手术病理证实的肾癌患者资料，所有患者均行2次DKI扫描(b value = 600 s/mm²)，对比分析前后2次DKI差异，主要包括弥散(Mean Diffusivity, MD)，表现各向异性(Fractional Anisotropy, FA)，峰度各向异性(Kurtosis Anisotropy, KA)，并评估各参数测量的可重复性。采用配对t检验进行比较。结果：前后2次测量的MD、KA值两两比较无统计学差异(P > 0.05)，两者的可重复性相似。结论：DKI技术诊断肾细胞癌是可行的，MD、KA的参数可重复性较好。

Abstract: Background: To investigate the feasibility and parameter measurement reproducibility of Diffusion Kurtosis Imaging (DKI) of renal cell carcinoma (RCC). Methods: 48 patients with RCC underwent DKI examination twice using same sequences and parameter setting with 3.0 T Philips MR scanner. Mean Diffusivity, (MD), Kurtosis Anisotropy (KA) maps were generated and measured. MD and KA values were calculated and compared. The reproducibility of MD and KA was also evaluated. Results: MD and KA values of all patients during two examinations showed no significant difference (P > 0.05), the reproducibility of the average MD and KA values of two examinations was similar. Conclusion: DKI is feasible and reproducible for the diagnosis of RCC; the reproducibility of the MD and KA values was good.