阿尔兹海默症发病相关蛋白互作网络构建与通路分析
Protein-Protein-Interaction Network and Pathway Analysis Related to Alzheimer’s Disease
DOI: 10.12677/HJBM.2018.82003, PDF,   
作者: 徐煜宸：中南大学湘雅医院神经内科，湖南 长沙；魏 琳：中南大学湘雅医学院，湖南 长沙；李泓磊：中南大学湘雅三医院耳鼻喉科，湖南 长沙
关键词: 阿尔兹海默症；蛋白互作网络；功能富集分析；Alzheimer’s Disease； Protein-Protein-Interaction Network； Functional Enrichment Analysis
摘要: 阿兹海默症(Alzheimer’s diseas, AD)是最常见的神经退行性疾病，其发病机制尚未完全明确。本文拟从基因表达综合数据库GEO (Gene Expression Omnibus)数据库中获取大样本量的AD患者的转录组数据，通过分析得到AD风险基因集，以AD风险基因集为基础，构建AD相关风险基因的蛋白互作网络发掘枢纽基因。同时利用功能富集分析和通路分析探索AD发病过程中涉及的生物学过程和信号通路，从而为阐明阿尔兹海默病的致病机制和探索阿尔兹海默病的防治新思路提供指导。
Abstract: Alzheimer's disease (AD) is one of the most common neurodegenerative disease, and its pathogenesis is not fully understood. This article derives transcriptome data of patients with AD from the Gene Expression database GEO (Gene Expression Omnibus), through which we obtain the AD-related risk gene set. Based on AD risk gene set, we construct a protein-protein-interaction network of AD. At the same time we used functional enrichment analysis and path analysis to explore the biological processes and signal pathway involved in AD. Our work helps to elucidate the pathogenic mechanism of AD and provide guidance to the future prevention and treatment of AD.
文章引用：徐煜宸, 魏琳, 李泓磊. 阿尔兹海默症发病相关蛋白互作网络构建与通路分析[J]. 生物医学, 2018, 8(2): 16-26. https://doi.org/10.12677/HJBM.2018.82003

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