肺癌代谢组学研究进展
Advances in Research of Metabolomics in Lung Cancer
DOI: 10.12677/ACM.2018.82023, PDF,   
作者: 刘吟絮：上海中医药大学附属龙华医院，上海
关键词: 代谢组学；肺癌；氨基酸；糖酵解；证型；Metabolomics； Lung Cancer； Amino Acid； Glycolysis； Syndrome
摘要: 代谢组学研究能灵敏地鉴定出基因和环境因素作用而产生的特定代谢型，在环境变化对机体产生作用的研究中具有优势。本文分别阐述了肺癌在氨基酸代谢、脂代谢、糖代谢方面的研究进展，为临床诊断提供了新途径，更为肺癌治疗提供了新的靶点。此外，应用代谢组学来阐释疾病发生发展的过程, 与中医的整体观念和辨证论治思维方式不谋而合，本文综述了肺癌代谢组学与肺癌中医证型之间的联系，为阐明中医证候及辨证论治的内涵奠定了理论基础。
Abstract: Metabolomics studies can sensitively identify the specific metabolic patterns produced by genetic and environmental factors, and have an advantage in the study of the role of environmental changes in body production. This paper expounds the lung cancer in amino acid metabolism, lipid metabolism, glucose metabolism of research progress, which provides a new way for the clinical diagnosis and new targets for cancer treatment. In addition, the application of metabolomics to il-lustrate the development of the disease process happens to have the same view of the overall concept and differential Treatment. This paper summarizes the relationship between the lung cancer metabolomics and the syndromes, and lays a theoretical foundation for elucidation of TCM syndromes and syndrome differentiation.
文章引用：刘吟絮. 肺癌代谢组学研究进展[J]. 临床医学进展, 2018, 8(2): 135-140. https://doi.org/10.12677/ACM.2018.82023

参考文献

[1] Nicholson, J.K., et al. (2002) Metabonomics: A Platform for Studying Drug Toxicity and Gene Function. Nature Re-views Drug Discovery, 1, 153-161.
[Google Scholar] [CrossRef] [PubMed]
[2] Cairns, R., Papandreou, I. and Denko, N. (2006) Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment. Molecular Cancer Research: MCR, 4, 61-70.
[Google Scholar] [CrossRef] 
[3] Dang, N.H., et al. (2014) Targeted Cancer Therapeutics: Biosynthetic and Energetic Pathways Characterized by Metabolomics and the Interplay with Key Cancer Regulatory Factors. Current Pharmaceutical Design, 20, 2637-2647.
[Google Scholar] [CrossRef] [PubMed]
[4] Beger, R.D. (2013) A Review of Applications of Metabo-lomics in Cancer. Metabolites, 3, 552-574.
[Google Scholar] [CrossRef] [PubMed]
[5] Dettmer, K., Aronov, P.A. and Hammock, B.D. (2007) Mass Spec-trometry-Based Metabolomics. Mass Spectrometry Reviews, 26, 51-78.
[Google Scholar] [CrossRef] [PubMed]
[6] Kwon, H., et al. (2015) Cancer Metabolomics in Basic Science Perspective. Archives of Pharmacal Research, 38, 372-380.
[Google Scholar] [CrossRef] [PubMed]
[7] Siegel, R., et al. (2014) Cancer Statistics, 2014. CA: A Cancer Journal for Clinicians, 64, 9-29.
[Google Scholar] [CrossRef] [PubMed]
[8] Maeda, J., et al. (2010) Possibility of Multivariate Function Composed of Plasma Amino Acid Profiles as a Novel Screening Index for Non-Small Cell Lung Cancer: A Case Control Study. BMC Cancer, 10, 690.
[Google Scholar] [CrossRef] [PubMed]
[9] Miyagi, Y., et al. (2011) Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection. PLoS One, 6, e24143.
[Google Scholar] [CrossRef] [PubMed]
[10] Shingyoji, M., et al. (2013) The Significance and Robustness of a Plasma Free Amino Acid (PFAA) Profile-Based Multiplex Function for Detecting Lung Cancer. BMC Cancer, 13, 77.
[Google Scholar] [CrossRef] [PubMed]
[11] Huang, C. and Freter, C. (2015) Lipid Metabolism, Apoptosis and Cancer Therapy. International Journal of Molecular Sciences, 16, 924-949.
[Google Scholar] [CrossRef] [PubMed]
[12] Santos, C.R. and Schulze, A. (2012) Lipid Metabolism in Cancer. FEBS Journal, 279, 2610-2623.
[Google Scholar] [CrossRef] [PubMed]
[13] Migita, T., et al. (2008) ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer. Cancer Research, 68, 8547-8554.
[Google Scholar] [CrossRef] 
[14] Go, M.K., et al. (2014) Glycine Decarboxylase Is an Un-usual Amino Acid Decarboxylase Involved in Tumorigenesis. Biochemistry, 53, 947-956.
[Google Scholar] [CrossRef] [PubMed]
[15] Zhang, W.C., et al. (2012) Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis. Cell, 148, 259-272.
[Google Scholar] [CrossRef] [PubMed]
[16] Saddoughi, S.A., Song, P. and Ogretmen, B. (2008) Roles of Bi-oactive Sphingolipids in Cancer Biology and Therapeutics. Subcellular Biochemistry, 49, 413-440.
[Google Scholar] [CrossRef] [PubMed]
[17] Cuvillier, O. (2008) Downregulating Sphingosine Kinase-1 for Cancer Therapy. Expert Opinion on Therapeutic Targets, 12, 1009-1020.
[Google Scholar] [CrossRef] [PubMed]
[18] Yu, X., et al. (2013) Metabonomics Study of Lung Cancer Cells Based on Liquid l Chromatography-Mass Spectrometry. Sepu, 31, 691-696.
[Google Scholar] [CrossRef] 
[19] Ferreira, L.M. (2010) Cancer Metabolism: The Warburg Effect Today. Experimental and Molecular Pathology, 89, 372-380.
[Google Scholar] [CrossRef] [PubMed]
[20] Kliewer, K.L., Ke, J.Y., Tian, M., et al. (2015) Adipose Tissue Lipolysis and Energy Metabolism in Early Cancer Cachexia in Mice. Cancer Biology & Therapy, 16, 886-897.
[Google Scholar] [CrossRef] [PubMed]
[21] Fearon, K.C., Glass, D.J. and Guttridge, D.C. (2012) Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways. Cell Metabolism, 16, 153-166.
[Google Scholar] [CrossRef] [PubMed]
[22] Csibi, A., Fendt, S.M., Li, C., et al. (2013) The mTORC1 Path-way Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4. Cell, 153, 840-854.
[Google Scholar] [CrossRef] [PubMed]
[23] 贾伟, 等. 代谢组学在中医药复杂理论体系研究中的应用[J]. 中国中药杂志, 2006(8): 621-624.
[24] 刘嘉湘. 中医药治疗肺癌研究思路和临床经验[J]. 世界中医药, 2007(2): 67-70.
[25] 马俊杰, 王小龙, 刘会平. 不同证型非小细胞肺癌患者肿瘤组织代谢组学研究[J]. 中国中西医结合杂志, 2015(6): 659-663.
[26] 周贤梅, 尤寅骏. 肺癌痰湿蕴肺证、气阴两虚证患者呼出气冷凝液的代谢组学研究[J]. 辽宁中医杂志, 2012(7): 1214-1218.
[27] 肖飞. 从循证医学到精准医学的思考[J]. 中华肾病研究电子杂志, 2014(3): 123-128.
[28] 魏聪, 吴以岭. 代谢组学及其在中医药现代化研究中的应用进展[J]. 疑难病杂志, 2009(11): 698-700.

为你推荐