高危复发胃癌术后予香菇多糖维持治疗的临床观察

Clinical Observation of Immunization Maintenance Treatment with Lentinan on Postoperative Gastric Cancer with High Risk Recurrence

摘要: 目的：高危复发胃癌术后予香菇多糖维持治疗的临床获益。方法：收集2011~2012年高危复发胃癌术后病人，术后化疗1~6次后，予香菇多糖2 mg/周免疫维持治疗(>6月) 39例，未行香菇多糖免疫维持治疗26例，比较其对中位疾病进展时间及总生存期的影响。结果：予香菇多糖维持治疗病人的总生存期及无病生存期较未行香菇多糖维持治疗的长。差异有统计学意义。结论：高危复发胃癌术后病人推荐予香菇多糖维持治疗。

Abstract: Objective: To investigate the clinical benefit of immunization maintenance treatment with lentinan on postoperative gastric cancer with high risk recurrence. Methods: 65 cases of patients of postoperative gastric cancer with high risk recurrence from 2011 to 2012 were chosen and divided into two groups: Lentinan maintenance treatment group which were treated with one to six cycles chemotherapy, not with lentinan maintenance treatment group which were treated with four to six cycles chemotherapy. Lentinan dripped 2 mg once a week was lasted at least six months. Median time to disease progression (TTP) and overall survival (OS) were analyzed by Kaplan-Meier method. Results: The lentinan group prolong OS and TTP. Conclusion: Immunization maintenance treatment with lentinan is recommended for gastric cancer with high risk recurrence.