GDF-15、OPG、YKL-40与急性心肌梗死的相关性
Correlation between GDF-15, OPG, YKL-40 and Acute Myocardial Infarction
DOI: 10.12677/ACM.2018.82025, PDF,    科研立项经费支持
作者: 朱志强：承德医学院，河北 承德；郭靖涛, 张金艳, 周 江：承德医学院第二附属医院，河北 承德
关键词: 急性心肌梗死；生长分化因子；骨保护素；甲壳质酶蛋白40；AMI； AS； GDF-15； OPG； YKL-40
摘要: 目的：探讨急性心肌梗死患者的血清GDF-15、OPG、YKL-40的水平变化，分析它们与急性心肌梗死的相关性。方法：选取2016年8月~2017年8月在承德市中心医院心血管内科诊断为急性心肌梗死(AMI组)和冠脉造影正常(对照组)的患者共计80例，收集临床资料，测定生化指标，采用ELISA法测GDF-15、OPG、YKL-40血清水平。结果：与对照组比较，AMI组患者年龄、性别、吸烟、血糖(Glu)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平差异均有统计学意义(P < 0.05)；AMI组GDF-15、OPG、YKL-40血清水平明显高于对照组(P < 0.01)；AMI组GDF-15、OPG、YKL-40血清水平与Glu、TC、TG、LDL-C呈强正相关性。结论：GDF-15、OPG、YKL-40水平的升高与AMI有明显相关性，联合检测GDF-15、OPG、YKL-40可作为心肌梗死监测指标。
Abstract: Objective: To explore the changes in serum levels of GDF-15, OPG and YKL-40 in patients with acute myocardial infarction (AMI) and to analyze their correlation with acute myocardial infarction (AMI). Methods: A total of 80 cases were selected from the Department of Cardiology, Chengde Central Hospital from August 2016 to August 2017, in which 40 patients with acute myocardial infarction were regarded as observation group (AMI group) and 40 patients with normal coronary angiography were regarded as control group (control group). Clinical data were collected and the biochemical criteria were determined. The serum levels of GDF-15, OPG and YKL-40 were measured by ELISA. Results: Compared with the control group, the differences of age, smoking, Glu, TC, TG and LDL-C in AMI patients were statistically significant (P < 0.05). The serum levels of GDF-15, OPG and YKL-40 in AMI group were significantly higher than those in control group (P < 0.01), showing a strong positive correlation with Glu, TC, TG and LDL-C. Conclusion: The increase of GDF-15, OPG and YKL-40 levels has a significant correlation with AMI. The combined detection of GDF-15, OPG and YKL-40 can be used as a marker of myocardial infarction.
文章引用：朱志强, 郭靖涛, 张金艳, 周江. GDF-15、OPG、YKL-40与急性心肌梗死的相关性[J]. 临床医学进展, 2018, 8(2): 148-153. https://doi.org/10.12677/ACM.2018.82025

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