瘦素受体基因(LEPR)的系统发育分析

Phylogenetic Analysis of Leptin Receptor Gene (LEPR)

摘要: 瘦素受体基因是控制肥胖的基因，它作为肥胖基因家族的成员广泛存在于灵长类动物中。LEPR (leptin receptor)为瘦素受体编码基因，由该基因编码的蛋白可以识别和转运瘦素。瘦素是一种和肥胖密切相关的蛋白，它能够调节灵长类动物的体重、能量代谢和免疫应答等通路，最终导致超重或者肥胖的发生。下载NCBI数据库中灵长类动物的核苷酸序列，用blast+程序进行序列比对，然后用Colinear Scan和MC scan X进行共线性分析，采用MEGA7.0中的最小平行进化法和最大同步法构建系统发育树。序列分析显示，灵长类动物中大多含有瘦素受体基因，且保守性较高。

Abstract: The leptin receptor gene is a gene that controls obesity, and is widely found in primates as members of the obesity gene family. Leptin receptor is the leptin receptor encoding gene, which is encoded by the protein to identify and transport leptin. Leptin is a protein closely related to obesity, which regulates the body’s weight, energy metabolism and immune response pathways, leading to overweight or obesity. Downloading the nucleotide sequence of primates in NCBI databases, conducting sequence alignment using blast+ applications, and then using the Colinear Scan MC and scan X to do collinearity analysis, adopting minimum parallel evolution method and maximal synchronization method in MEGA7.0 to construct phylogenetic tree, sequence analysis shows that most primates have leptin receptor genes which are more conservative.