纳布啡的药理学和临床应用进展
Advance in Research on the Pharmacology and Clinical Use of Nalbuphine
DOI: 10.12677/ACM.2018.83049, PDF,   
作者: 朱昌茂, 王 聪, 张咸伟：华中科技大学同济医学院附属同济医院麻醉科，湖北 武汉
关键词: 纳布啡；药理学；临床应用；Nalbuphine； Pharmacology； Clinical Use
摘要: 纳布啡是一种吗啡喃类半合成激动–拮抗镇痛药，分子式C21H27NO4，结构上类似于阿片受体拮抗剂纳洛酮和强效阿片类镇痛药羟吗啡酮，主要通过激动κ受体、拮抗μ受体发挥药理作用。镇痛效价与吗啡类似，但副作用较少，安全性较高，主要应用于中重度疼痛的治疗。
Abstract: Nalbuphine is a synthetic opioid agonist-antagonist analgesic derivative of the phenanthrene group, and its structure is C21H27NO4, similar to those of naloxone and oxymorphone. It acts as a mu-opioid receptor antagonist and kappa-opioid receptor agonist, with analgesic potency equivalent to morphine and better safety profile. Nalbuphine is mainly used to treat and prevent moderate to severe pain.
文章引用：朱昌茂, 王聪, 张咸伟. 纳布啡的药理学和临床应用进展[J]. 临床医学进展, 2018, 8(3): 289-294. https://doi.org/10.12677/ACM.2018.83049

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