基于傅里叶功率谱的H1N1病毒血凝素蛋白质序列的比较分析
Comparison and Analysis of H1N1 Hemagglutinin Protein Sequences Based on Fourier Power Spectrum
DOI: 10.12677/HJCB.2018.81003, PDF,    科研立项经费支持
作者: 王华*, 白凤兰, 刘立伟：大连交通大学理学院，辽宁 大连
关键词: 蛋白质序列；傅里叶变换；功率谱；聚类；Protein Sequence； Fourier Transform； Power Spectrum； Clustering
摘要: 基于经典的HP模型，将不同特征下的H1N1病毒血凝素蛋白质序列转换为数字序列并且用离散傅里叶变换求出相应序列的功率谱。根据这些功率谱建立数学矩函数，并将数字序列转换为多维的矩向量，得到蛋白质序列对应的特征向量。再利用特征向量之间的中间距离对蛋白质序列进行聚类比较分析，得到了较好的结果。这一方法将不同长度的蛋白质序列通过功率谱和力矩将其转化为相同维数的向量，使我们更加容易比较分析生物序列。
Abstract: Based on the classical HP model, the H1N1 hemagglutinin protein sequence under different characteristics was converted into a digital sequence and the power spectrum of the corresponding sequence was calculated using a discrete Fourier transform. According to these power spectra, a mathematical moment function is established, and the digital sequence is converted into a multi-dimensional moment vector to obtain the corresponding feature vector of the protein sequence. Then using the middle distances between the feature vectors to compare and analyze the protein sequences, a good result was obtained. This method converts protein sequences of different lengths through power spectrum and moments into vectors of the same dimension, which makes it easier for us to compare and analyze biological sequences.
文章引用：王华, 白凤兰, 刘立伟. 基于傅里叶功率谱的H1N1病毒血凝素蛋白质序列的比较分析[J]. 计算生物学, 2018, 8(1): 15-23. https://doi.org/10.12677/HJCB.2018.81003

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