赤芍承气汤灌肠治疗乙肝相关慢加急性肝衰竭前期的疗效分析

Clinical Effect Analysis on Hepatitis B Virus Acute-on-Chronic Pre-Liver Failure by Chishao Chengqi Enema

摘要: 目的：观察赤芍承气汤灌肠治疗乙肝相关慢加急性肝衰竭前期的临床疗效并进行分析和探讨。方法：对2015年10月至2016年12月期间我科收治的乙肝相关慢加急性肝衰竭前期的30例患者进行随机为治疗组和对照组，治疗组在常规内科综合治疗基础上加用赤芍承气汤保留灌肠，隔天1次，每次200 ml，连续治疗4周，观察治疗前后两组的肝功能、凝血功能及血氨的治疗效果并进行比较。结果：比较两组患者的肝功能(ALT, AST, TB, ALB)、凝血功能(PTA)、血氨，治疗组明显优于对照组(P < 0.05)；治疗组并发症发生率明显低于对照组(P < 0.05)；治疗总有效率治疗组为86.7%，对照组为66.7%，两组对比差异有显著性意义(P < 0.05)；治疗组较对照组并发症的发生、肝功能衰竭发展明显降低。结论：赤芍承气汤可明显改善乙肝相关慢加急性肝衰竭前期患者肝功能，减少并发症，改善预后。

Abstract: Objective: To investigate the clinical effect of Chishao Chengqi Enema in treating Hepatitis B virus (HBV)-related acute-on-chronic pre-liver failure. Methods: Internalize 30 patients accepted by our department from 2015 October to 2016 December, and divide them at random into therapeutic group and control group. All of the groups got normal complex therapies, on the base of these, the therapeutic group was treated with Chishao Chengqi enema. Once every other day, 200 ml each time and last for 4 weeks. After that, we will compare the results of the treatment, including Liver Function, Coagulation Function and Blood Ammonia, with the results before the treatment. Results: Compare the results of the two groups, we will find the results of Liver Function (ALT, AST, TB, ALB), Coagulation Function (PTA), and the Blood Ammonia of the Treatment Group are much better than the Control Group (P < 0.05). The rate of complication is far lower than the Control Group (P < 0.05). The efficiency rate of the Treatment Group is 86.7%, and the efficiency rate of the Control Group is 66.7%. There is great difference between the efficiency rates (P < 0.05). The possibility of complication and hepatic failure will be lower if we take the Chishao Chengqi enema treatment. Conclusion: Chishao Chengqi enema can effectively improve the Liver Function of patients with HBV-related acute-on-chronic pre-liver failure, and decrease the possibility of complication.