氟喹诺酮酸酯的ESI-MS裂解研究
Study on the ESI-MS Dissociation of Fluoroquinolone Acid Esters
DOI: 10.12677/JOCR.2018.62007, PDF,    科研立项经费支持
作者: 陈嘉豪, 莫洛淇, 雷颖欣, 游权稳, 汤日元*：华南农业大学，材料与能源学院应用化学系，广东 广州
关键词: 喹诺酮；脱羧偶联；质谱；Quinolones； Decarboxylation Coupling； Mass Spectrometry
摘要: 氟喹诺酮酸酯对养殖业和人类健康存在潜在危害，发展其分析检测方法具有重要的意义。本论文制备了七种氟喹诺酮酸酯，并在ESI质谱仪的正离子测试模式下，获取它们的MS2裂解图谱。结果显示七种氟喹诺酮酸酯均优先断裂酯基中的C-O键，产生三种高强度的碎片离子峰：[M+H]+、[M+2H-Y]+和[M-Y-16]+ (Y为酯基中烷基的质量数)。这些碎片可以作为定性离子，用于鉴定氟喹诺酮酸酯。
Abstract: Fluoroquinolone acid esters have potential hazards to the breeding industries and human health, so it is of vital significance to develop its analysis and detection methods. In this paper, seven kinds of fluoroquinolone acid esters were prepared. The ESI-MS2 dissociation spectrograms of these compounds were obtained under the positive ions test mode of mass spectrometry. The results showed that the C-O bonds of ester groups in these fluoroquinolone acid esters were preferentially fractured. Three fragmentation ion peaks with high intensities were found. It includes [M+H]+, [M+2H-Y]+, and [M-Y-16]+ (Y refers to the mass number of alkyl groups in ester groups). These fragmentation ions could be used as qualitative ions for the identification of fluoroquinolone acid esters.
文章引用：陈嘉豪, 莫洛淇, 雷颖欣, 游权稳, 汤日元. 氟喹诺酮酸酯的ESI-MS裂解研究[J]. 有机化学研究, 2018, 6(2): 45-51. https://doi.org/10.12677/JOCR.2018.62007

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