Brønsted酸性离子液体催化Biginelli反应合成3,4-二氢嘧啶-2(1H)-(硫)酮类化合物
Brønsted Acid Ionic Liquid Catalyzed Biginelli Reaction to Synthesize 3,4-Dihydropyrimidine-2(1H)-(Thio)ones Compounds
DOI: 10.12677/SSC.2018.62005, PDF,    国家自然科学基金支持
作者: 郭瑞, 刘秀梅, 刘晨江*：石油天然气精细化工教育部&自治区重点实验室，新疆大学化学化工学院，新疆 乌鲁木齐
关键词: 离子液体；Biginelli反应；催化；3；4-二氢嘧啶-2(1H)-(硫)酮；Ionic Liquid； Biginelli Reaction； Catalysis； 3；4-Dihydropyrimidine-2(1H)-(Thio)ones
摘要: 离子液体4-苯基-3-丙基磺酸基四氢噻唑-2-硫酮硫酸氢盐催化芳香醛、1,3-二羰基化合物和脲或硫脲发生Biginelli反应合成了一系列3,4-二氢嘧啶-2(1H)-(硫)酮类化合物。本实验方法操作简单、反应条件温和、后处理方便。离子液体催化剂重复使用6次后，产率无明显变化。
Abstract: A series of 3,4-dihydropyrimidine-2(1H)-(thio)ones were synthesized via the Biginelli reaction of aromatic aldehydes, 1,3-dicarbonyl compounds and urea or thiourea catalyzed by ionic liquid 4-phenyl-3-(3-sulfopropyl)tetrahydrothiazole-2-thione hydrogen sulfate. The experiment method has the advantages of simple operation, mild reaction condition, and convenient treatment. When the ionic liquid catalyst was reused for 6 times, the yield had no obvious change.
文章引用：郭瑞, 刘秀梅, 刘晨江. Brønsted酸性离子液体催化Biginelli反应合成3,4-二氢嘧啶-2(1H)-(硫)酮类化合物[J]. 合成化学研究, 2018, 6(2): 29-36. https://doi.org/10.12677/SSC.2018.62005

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