布朗斯特酸性离子液体[DC2O2IM][p-CH3PhSO3]催化Biginelli三组分反应的研究
Research of Biginelli Three-Component Reaction Catalyzed by Br?nsted Acidic Ionic Liquid [DC2O2IM][p-CH3PhSO3]
DOI: 10.12677/JOCR.2018.62010, PDF,  被引量    国家自然科学基金支持
作者: 张海燕, 李 贺, 刘晨江*:新疆大学化学化工学院,石油天然气精细化工教育部&自治区重点实验室,新疆 乌鲁木齐
关键词: 离子液体催化Biginelli反应34-二氢嘧啶-2(1H)-酮/硫酮Ionic Liquid Catalysis Biginelli Reaction 34-Dihydropyrimidin-2(1H)-Ones/Thiones
摘要: 本文报道了布朗斯特酸性离子液体1,3-二羧甲基咪唑对甲苯磺酸盐作为一种绿色、环境友好的催化剂,成功地催化Biginelli三组分反应合成了一系列3,4-二氢嘧啶-2(1H)-酮或硫酮化合物。该方法具有条件温和、产率高、反应时间短的优点。此外,催化剂离子液体可循环使用五次且催化活性没有明显降低。
Abstract: In this paper, a series of 3,4-hydropyrimidine-2(1H)-ones/thiones was synthesized via the Biginelli three-component reaction using the Brønsted acidic ionic liquid 1,3-dicarboxy methylimidazole p-toluenesulfonate as a green and environmentally friendly catalyst. The method has the advantages of mild conditions, high yield, and short reaction time. In addition, the catalyst ionic liquid can be recycled five times without significant reduction in catalytic activity.
文章引用:张海燕, 李贺, 刘晨江. 布朗斯特酸性离子液体[DC2O2IM][p-CH3PhSO3]催化Biginelli三组分反应的研究[J]. 有机化学研究, 2018, 6(2): 61-68. https://doi.org/10.12677/JOCR.2018.62010

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