部分脾动脉栓塞治疗成人慢性难治性免疫性血小板减少症临床研究

Clinical Research on the Treatment of Adult Refractory Immune Thrombocytopenia with Modified Splenic Artery Embolization

摘要: 目的：探讨部分脾动脉栓塞术(PSE)对成人难治性免疫性血小板减少症(ITP)的临床疗效。方法：选取16例难治性ITP内科治疗无效患者进行部分PSE治疗。对患者术前及术后1周、1、3个月进常规(血小板、白细胞)监测，对患者临床治疗效果进行分析。结果：16例难治性ITP患者进行部分PSE治疗后，显效11例(68.75%)，良效2例(12.5%)，无效3例。治疗前后血小板数比较差异均有统计学意义(P < 0.05)。结论：部分PSE临床疗效满意，且操作简单，创伤小，并发症少，保留了脾脏的免疫功能，是治疗难治性ITP安全有效的方法。

Abstract: Objective: To investigate the clinical efficacy of modified partial splenic artery embolization (PSE) in the treatment of Adult Refractory Immune Thrombocytopenia (ITP). Methods: A total of 16 patients with refractory ITP were treated with modified PSE. The 1evels of platelets, white blood cells were monitored before and at 7, 30, 90 days after operation. The clinical curative effect was observed and evaluated. Results: After modified PSE, there was significant effect in 11 cases (68.75%), good effect in 2 cases (12.5%), and no effect in 3 cases, with statistically significant difference before and after treatment (P < 0.05). Conclusion: The clinical curative effect of modified PSE is satisfactory with simple operation, less trauma and less complication. PSE is a safe and effective method for the treatment of refractory adult ITP.