耦合Pre-BO¨ tzinger复合体神经元中混合簇放电模式的研究
Mixed Bursting of Coupled Neuron in the Pre-BO¨ tzinger Complex
DOI: 10.12677/DSC.2018.73017, PDF,    国家自然科学基金支持
作者: 王子剑, 马 芬, 梁桐桐：北方工业大学理学院，北京
关键词: 呼吸系统；Pre-BO¨ tzinger复合体；混合簇放电；分岔；Respiratory System； Pre-BO¨ tzinger Complex； Mixed Bursting； Bifurcation
摘要: Pre-Bötzinger复合体是新生哺乳动物呼吸节律起源的关键部位，是呼吸节律产生的中枢。本文以pre-Bötzinger复合体中两个耦合的神经元为研究对象，并考虑钙离子动力学的耦合神经元模型。利用快慢动力学和分岔分析，研究混合簇同步放电模式及其产生机制。结果表明钙离子的周期性波动对混合簇放电模式的产生有极大的影响，钙离子的波动及分岔曲线相对位置的改变是混合簇放电产生的主要原因。
Abstract: The pre-Bötzinger complex is a kernel part in brainstem region that generates respiratory rhythm, and it is the center in control of respiratory pattern in mammals. In this paper, based on the Butera model, two-coupled neuron networks including the dynamics of calcium ion in the Pre-Bötzinger complex are studied. The generation mechanism and synchronous discharge of mixed bursting are studied. The results show that periodic fluctuation of calcium ions has a great influence on the generation of the mixed bursting, so as the relative position of bifurcation curves.
文章引用：王子剑, 马芬, 梁桐桐. 耦合Pre-BO¨ tzinger复合体神经元中混合簇放电模式的研究[J]. 动力系统与控制, 2018, 7(3): 154-161. https://doi.org/10.12677/DSC.2018.73017

参考文献

[1] Best, J., Borisyuk, A., Rubin, J., et al. (2005) The Dynamic Range of Bursting in a Model Respiratory Pacemaker Network. SIAM Journal on Applied Dynamical Systems, 4, 1107-1139.
[Google Scholar] [CrossRef] 
[2] Ramirez, J.M., Quellmalz, U.J. and Richter, D.W. (1996) Postnatal Changes in the Mammalian Respiratory Network as Revealed by the Transverse Brain Stem Slice of Mouse. J. Physiol., 491, 799-812.
[Google Scholar] [CrossRef] [PubMed]
[3] Ramirez, J.M., Koch, H., Garcia III, A.J., Doi, A. and Zanella, S. (2011) The Role of Spiking and Bursting Pacemakers in the Neuronal Control of Breathing. The Journal of Physiology, 37, 241-261.
[Google Scholar] [CrossRef] [PubMed]
[4] Smith, J.C., Ellenberger, H.H., Ballanyi, K., Richter, D.W. and Feldman, J.L. (1991) Pre-Bötzinger Complex: A Brain Stem Region That May Generate Respiratory Rhythm in Mammal. Science, 254, 726-729.
[Google Scholar] [CrossRef] [PubMed]
[5] Ivanchenko, M.V., Osipov, G.V., Shalfeev, V.D., et al. (2004) Phase Synchronization in Ensembles of Bursting Oscillators. Physical Review Letters, 93, 101-134.
[Google Scholar] [CrossRef] 
[6] Ivanchenko, M.V., Osipov, G.V., Shalfeev, V.D., et al. (2007) Network Mechanism for Burst Generation. Physical Review Letters, 98, 101-108.
[Google Scholar] [CrossRef] 
[7] Pace, R.W., Mackay, D.D., Feldman, J.L. and Negro, C.A.D. (2007) Role of Persistent Sodium Current in Mouse Pre-Bötzinger Complex Neurons and Respiratory Rhythm Generation. The Journal of Physiology, 580, 485-496.
[Google Scholar] [CrossRef] [PubMed]
[8] Wang, Y.Y., Jonathan, E. and Rubin, J. (2016) Multiple Timescale Mixed Bursting Dynamics in a Respiratory Neuron Model. Journal of Computational Neuroscience, 41, 245-268.
[Google Scholar] [CrossRef] [PubMed]
[9] Mironov, S.L. (2008) Metabotropic Glutamate Re-ceptors Activate Dendritic Calcium Waves and TRPM Channels Which Drive Rhythmicre Spiratory Patterns in Mice. Journal of Physiology, 586, 2277-2291.
[Google Scholar] [CrossRef] [PubMed]
[10] Toporikova, N. and Butera, R.J. (2011) Two Types of Inde-pendent Bursting Mechanisms in Inspiratory Neurons: An Integrative Model. Journal of Computational Neuroscience, 30, 515-528.
[Google Scholar] [CrossRef] [PubMed]

为你推荐