间甲基苯脒肟的微波超声波催化合成

Microwave-Assisted Ultrasound Catalytic Synthesis of m-Met-Hylbenzamidoxime

摘要: 本文以间甲基苯腈和盐酸羟胺为原料，在催化剂作用下，通过微波和超声波的共同作用，合成间甲基苯脒肟。基于间甲基苯脒肟的产率为评价指标，进行了L₉ (3³)的正交试验，考察了催化剂的种类、微波功率、反应时间三个因素。结果表明：催化剂种类对反应影响最大，反应时间次之，而微波功率则影响最小。在不考虑反应物配比和超声波强度的情况下，采用苄基三乙基氯化铵作催化剂，微波功率400 W以及反应时间20分钟为最优的反应条件。

Abstract: In this paper, m-methylbenzamidoxime was synthesized from m-methyl-phenylnitrile and hydrox-ylamine hydrochloride by microwave and ultrasonic with catalyst. Based on the yield of m-methylbenzamidoxime as an evaluation index, an orthogonal test of L₉ (3³) was carried out to examine the three factors of the type of catalyst, microwave power, and reaction time. It is shown that influence of the catalyst on the reaction is the most, and the second is reaction time, and mi-crowave power has minimal influence. The optimum reaction conditions were that three factors: the catalyst of the benzyltriethylammonium chloride, the microwave power of 400 W, and reaction time of 20 minutes, without considering the reactant mix ratio and the ultrasonic intensity.