长链非编码RNA MEG3在肿瘤发生中的研究进展
Research Advancements of Long Non-Coding RNA MEG3 in Tumor
DOI: 10.12677/ACM.2018.85075, PDF,    科研立项经费支持
作者: 周 晶：泰州市人民医院肿瘤科，江苏 泰州；田 野：泰州市人民医院普外科，江苏 泰州
关键词: 长链非编码RNA；MEG3；肿瘤；Long Non-Coding RNA； MEG3； Tumor
摘要: 长链非编码RNA(lncRNA)是一类长度超过200 nt (核苷酸)的功能性RNA分子，以RNA的形式在多种层面(表观遗传学、转录水平、转录后水平等)上调控基因的表达。在肿瘤的发生、发展过程中发挥着重要的作用。母系表达基因MEG3是第一个被发现具有肿瘤抑制功能的lncRNA。众多研究表明lncRNA MEG3表达于多种正常组织，而在大多数肿瘤组织或肿瘤细胞株中不表达。本文总结了lncRNA MEG3在研究方面取得的进展，主要就lncRNA MEG3在肿瘤发生发展中的作用作一综述。
Abstract: Long non-coding RNAs (lncRNAs, > 200 nt) were reported more recently. Most lncRNAs play im-portant biological roles in tumorigenesis through different mechanisms including epigenetic modification, alternative splicing, RNA decay, and post-translation modification regulation. MEG3, an imprinted gene, maternally expressed in humans, has been first identified as a tumor suppres-sor. The expression of MEG3 is lost or markedly reduced in several primary human tumors. In this review, we review the latest advancement of MEG3 in tumorigenesis.
文章引用：周晶, 田野. 长链非编码RNA MEG3在肿瘤发生中的研究进展[J]. 临床医学进展, 2018, 8(5): 454-459. https://doi.org/10.12677/ACM.2018.85075

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