肠道菌群与肿瘤耐药的研究进展

Research Progress on Tumor Resistance and Intestinal Microflora

摘要: 肿瘤是全球最难治疗的疾病之一，作为一种复杂的疾病，肿瘤严重影响机体免疫系统，物质代谢等生理功能。目前在临床上肿瘤的治疗有化学疗法，生物疗法，免疫疗法等，但使用这些治疗方法在临床上常常会出现耐药性，这是临床上亟待解决的问题之一。肠道菌群稳态时被称为人体的器官，肠道菌群稳态在机体生命活动中发挥着重要的作用，在促进宿主营养物质消化吸收、维持肠道正常生理功能、调节机体免疫以及拮抗病原微生物定植等方面有重要的生理意义。已有研究表明，肠道菌群的失调能够引起多种疾病，如肠黏膜受损，肠道炎症反应。肠道菌群失调与肿瘤耐药的机理已引起学者高度重视。

Abstract: Cancer is one of the most difficult diseases in the world. As a complex disease, the tumor seriously affects the body's immune system, material metabolism and other physiological functions. At pre-sent, the treatment of clinical tumors is chemical therapy, biotherapy, immunotherapy and so on. However, drug resistance often occurs in clinical treatment, which is an urgent problem to be solved in clinical. The homeostasis of intestinal flora is known as the organ of the human body. The homeostasis of intestinal flora plays an important role in the organism’s life activities. It has important physiological significance in promoting the digestion and absorption of the host nutrient, maintaining the normal physiological function of the intestine, regulating the immunity of the body and antagonizing the colonization of the pathogenic microorganism. Studies have shown that the imbalance of intestinal flora can cause many diseases, such as intestinal mucosal damage and intestinal inflammation. The mechanism of intestinal flora imbalance and drug resistance has at-tracted great attention from scholars.