FSHR、ER-α在胃癌组织中的免疫荧光分布及其与GnRHR的共定位观察

Distribution of FSHR and ER-α and Their Colocalization with GnRHR in Gastric Carcinoma

摘要: 目的：研究卵泡刺激素受体(FSHR)和雌激素受体α (ERα)在胃癌组织中的定位、分布及与促性腺激素释放激素受体(GnRHR)共存性。方法：采用免疫荧光化学定位方法。结果：胃癌组织上皮细胞呈FSHR和ERα免疫反应阳性；在胃癌组织中GnRHR免疫反应阳性细胞中观察到了FSHR免疫反应阳性的结果，其中大部分亦呈ERα免疫反应阳性，且分布模式相同；三种免疫反应阳性物质均分布在细胞质内，细胞核呈阴性。结论：GnRHR与FSHR或ERα在胃癌组织分布及其共存性上提示上述相关激素对胃癌的病理发生机制具有重要的影响。

Abstract: Objective: To investigate the distribution of follicle-stimulating hormone receptor (FSHR), estrogen receptorα (ERα) and colocalization with gonadotropin releasing hormone receptor (GnRHR) at the stomach cancer. Methods: Distribution of FSHR and ERα and their colocalization with GnRHR at the stomach cancer were investigated by immune fluorescent chemical registration method. Results: FSHR and ERα immunoreactivities were observed in the cytoplasm of the epithelial cells of stomach cancer respectively with negative nucleus. Conclusion: The colocalization of FSHR or ER-α with GnRHR immunoreactivities was also found in the same structures of two Gastric cancer tissue section. The distribution of gastric cancer tissue and colocalization of FSHR or ERα with GnRHR indicate that they might have an important influence on the stomach cancer pathology change.