NGF和PGE₂在女性OAB患者尿液中的表达及临床意义

Expression and Clinical Significance of NGF and PGE₂ in the Urine of Female Patients with Overactive Bladder

摘要: 目的：探讨女性膀胱过度活动患者尿液中NGF和PGE2的表达。方法：通过病史采集、尿液分析、排尿日记及尿流动力学检查将65位女性OAB患者纳入病例组，将20位正常女性志愿者纳入对照组。应用酶联免疫吸附试验检测两组患者尿液中NGF和PGE₂的表达水平。并对病例组患者尿液中NGF、PGE₂的水平与尿动力学参数变化之间的关联性进行分析。结果：NGF和PGE₂在病例组患者尿液中的表达明显高于对照组(p < 0.05)。病例组患者尿液中PGE₂的表达与患者初始尿意膀胱容量和膀胱最大容积呈正相关(p < 0.05)，而病例组患者尿液中NGF的表达与尿流动力学参数间无相关性。结论：NGF和PGE₂在女性OAB患者的疾病演进过程中发挥重要作用，尿液中这些因子的水平可作为评价OAB症状的潜在指标。

Abstract: Objects: We investigated changes in urinary NGF and PGE₂ in women with OAB. Methods: The study groups included 65 women with OAB and 20 without bladder symptoms who served as controls. Evaluation included patient history, urinalysis, a voiding diary and urodynamic studies. Urine samples were collected. NGF and PGE₂ were measured using enzyme-linked immunosorbent assay and compared between the groups. In addition, correlations between urinary NGF and PGE₂, and urodynamic parameters in patients with OAB were examined. Results: Urinary NGF and PGE₂ were significantly increased in patients with OAB compared with controls (p < 0.05). In patients with OAB urinary, PGE₂ positively correlated with volume at first desire to void and maximum cystometric capacity (p < 0.05). Urinary NGF did not correlate with urodynamic parameters in patients with OAB. Conclusions: NGF and PGE₂ have important roles in the development of OAB symptoms in female patients. Urinary levels of these factors may be used as markers to evaluate OAB symptoms.