氢溴酸东莨菪碱结晶工艺优化及结构表征
Crystallization Optimization and Structural Characterization of Scopolamine Hydrobromide
DOI: 10.12677/HJCET.2018.85036, PDF,  被引量    科研立项经费支持
作者: 陈朋朋*, 吴泽宇, 惠爱玲, 张文成：合肥工业大学食品科学与工程学院，农产品生物化工教育部工程研究中心，安徽 合肥；许 坤：安徽德信佳生物医药有限公司，安徽 阜阳
关键词: 氢溴酸东莨菪碱；冷冻结晶；结构表征；Scopolamine Hydrobromide； Freezing Crystallization； Structural Characterization
摘要: 本文论述了一种氢溴酸东莨菪碱的结晶工艺及其结构的表征。以东莨菪碱含量83%的洋金花提取物为原料，通过加酸成盐和冷冻结晶的方法，在对其纯化的同时得到临床用药氢溴酸东莨菪碱。考察了溶剂、结晶时间对结晶的影响，确定了溶剂为乙醇，结晶时间为8 h。制得的晶体经液相色谱检测其纯度为99.40%，算得回收率为73.24%。将制得的晶体经红外检测符合药典对其官能团的规定，经X-射线衍射分析表明结晶度较好。
Abstract: In this article, a preparation method of scopolamine hydrobromide by freezing crystallization was developed. After Flosdaturae extract with the purity of scopolamine of 83% dissolved, the purifi-cation of scopolamine and preparation of scopolamine hydrobromide were achieved by addition of hydrobromic acid to form the salt, and freezing crystallization. The influence of solvent and crystallization time was investigated on the crystallization process. The crystallization solvent was determined to be ethanol and the crystallization time was 8 h. The purity of scopolamine hy-drobromide crystals was determined to be 99.40% by high performance liquid chromatograpgy. And the recovery rate was 73.24%. The crystals were detected by Fourier infrared spectroscopy and the results showed that the functional groups meet the requirements in the pharmacopoeia. X-ray diffraction analysis showed that the crystallinity was better.
文章引用：陈朋朋, 吴泽宇, 许坤, 惠爱玲, 张文成. 氢溴酸东莨菪碱结晶工艺优化及结构表征[J]. 化学工程与技术, 2018, 8(5): 291-296. https://doi.org/10.12677/HJCET.2018.85036

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